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Repurposing of FDA-approved drugs promoting oligodendrogenesis for brain injury of the preterm

ABG-107048 Thesis topic
2022-08-05 Public/private mixed funding
INSERM U1208
Bron - Auvergne-Rhône-Alpes - France
Repurposing of FDA-approved drugs promoting oligodendrogenesis for brain injury of the preterm
  • Biology
  • Psychology, neurosciences
neural stem cells, postnatal brain injuries, cellular repair

Topic description

Project: Preterm-birth brain injury (PBI) is a major public health concern, with many surviving children developing cognitive and neuropsychiatric deficits. The developmental period around birth is a time of active generation of oligodendrocytes, myelination, and axonal reorganization that is strongly perturbed in many preterm-born children.  Through a pharmacogenomics analysis based on the generation and expert curation of transcriptomic datasets, we identified novel small bioactive molecules fostering oligodendrogenesis by acting on transcriptional programs underlying their proliferation or maturation. In this project, we will use cutting edge histological and transcriptional approaches to 1) dissect out the mode of action of these molecules, 2) investigate their potential effects on other lineages than oligodendroglia. This project, supported by the ANR (Project NeoReGen), and involves a close collaboration with the Parras team (ICM, Paris) and Gressens team (Diderot Hospital, Paris). For more background, see Azim et al., Plos Biol 2017, Donega et al., Cell Reports 2018, Marie C et al., PNAS, 2018.

 

 

Starting date

2022-11-01

Funding category

Public/private mixed funding

Funding further details

ANR

Presentation of host institution and host laboratory

INSERM U1208

Environment: You will join a multidisciplinary team of scientists. The SBRI benefits from state-of-the-art research platforms including Omics and Imaging, and provide a high-quality scientific, technological and medical environment.

PhD title

PhD in Neurosciences

Country where you obtained your PhD

France

Institution awarding doctoral degree

UCBL

Graduate school

Biologie moléculaire, intégrative et cellulaire (BMIC)

Candidate's profile

Candidates: We are looking for an enthusiastic and highly motivated scientist holding a M2 in neurosciences or cellular biology and willing to join a challenging research area. Experience in histology and bioinformatic analysis/scripting would be valuable. Strong communication skills, team spirit and ability to work in a multidisciplinary team are expected.

2022-09-30
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