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Long-term consequences of early metabolic brain insults on cortical networks organization and functional integrity

ABG-107049 Thesis topic
2022-08-05 Public/private mixed funding
INSERM U1208
Bron - Auvergne-Rhône-Alpes - France
Long-term consequences of early metabolic brain insults on cortical networks organization and functional integrity
  • Biology
  • Psychology, neurosciences
Postnatal brain injuries, energy metabolism, brain wiring, repair

Topic description

Project: This project is built on the unique expertise of our teams in postnatal brain development (Olivier Raineteau) and energy metabolism during neuron development (Julien Courchet) to unravel the consequences of premature brain injuries on circuits formation. This project, supported by the ANR (Project Rewired), aims at testing the hypothesis that alterations of the metabolic homeostasis during the critical period of plasticity leave a “metabolic scar”, leading to long-lasting alterations of the organization and function of neural circuits.  For more background, see Azim et al., Plos Biol 2017, Donega et al., Cell Reports 2018, Courchet et al., Nat Commun, 2018.

Starting date

2022-11-01

Funding category

Public/private mixed funding

Funding further details

ANR

Presentation of host institution and host laboratory

INSERM U1208

Environment: You will join a multidisciplinary team of scientists. The SBRI benefits from state-of-the-art research platforms including Omics and Imaging, and provide a high-quality scientific, technological and medical environment. The project will involve a close collaboration with the Courchet team in Lyon (INMG, Lyon).

PhD title

PhD in Neurosciences

Country where you obtained your PhD

France

Institution awarding doctoral degree

UNIVERSITE CLAUDE-BERNARD-LYON 1

Graduate school

Biologie moléculaire, intégrative et cellulaire (BMIC)

Candidate's profile

Candidates: We are looking for an enthusiastic and highly motivated scientist holding a M2 in neurosciences or cellular biology and willing to join a challenging research area. Experience in histology and bioinformatic analysis/scripting would be valuable. Strong communication skills, team spirit and ability to work in a multidisciplinary team are expected.

2022-09-30
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