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Synthesis of innovative peptide-lipid conjugates for the development of lipid nanocapsules for antibiotic delivery

ABG-120142 Thesis topic
2024-02-13 Public funding alone (i.e. government, region, European, international organization research grant)
Centre National de la Recherche Scientifique - Groupe
- Bretagne - France
Synthesis of innovative peptide-lipid conjugates for the development of lipid nanocapsules for antibiotic delivery
  • Chemistry
Organic chemistry, peptide synthesis, bioconjugation, lipids, formulation of lipid nanoparticles, encapsulation of active ingredients

Topic description

The research and development of new lipid nanoparticles for drug delivery has become a major area of research since the recent appearance of RNA-based vaccines against COVID19. A whole area of molecular engineering around lipids has been set up to propose new therapeutic approaches based on the use of lipid nanovectors in oncology, neurology, infectiology and vaccination. Although liposomes formed from standard phospholipids can be used to encapsulate active ingredients such as peptides and nucleic acids, their efficacy remains inadequate for several medical applications (particularly oral administration). The aim of the thesis project is to develop a new generation of lipid capsules with new functionalities capable of crossing current technological barriers (oral route) via the chemical functionalisation of natural lipids with peptides and formulation using microfluidic methodology. The encapsulation of antibiotic molecules will also be addressed during this research. The PhD student will work on the Villejean campus (Rennes) with Dr Charlène Gadais on the automated synthesis of peptides and at the Ecole Nationale Supérieure de Chimie de Rennes (Beaulieu campus, Rennes) with Professor Thierry Benvegnu, on the synthesis of peptide-lipid conjugates, their formulation in lipid nanocapsules and the encapsulation of active ingredients with antibiotic properties. Collaboration with teams of biologists and pharmacists in Angers, Rennes and Brest is also planned for the biological evaluations.

Starting date

2024-10-01

Funding category

Public funding alone (i.e. government, region, European, international organization research grant)

Funding further details

Presentation of host institution and host laboratory

Centre National de la Recherche Scientifique - Groupe

Our Organic Chemistry & Interfaces laboratory (CORINT), part of the UMR 6226 CNRS "Institut des Sciences Chimiques de Rennes", is located on the Beaulieu and Villejean campuses. The team's main objective is to develop organic-based molecular tools that address current and future fundamental and applied issues at the interface between biology and physics. For several years, we have been developing a research theme concerning the design and synthesis of extremophilic lipids (Archaea) for drug delivery applications. Our laboratory is associated with Ibisa's ISO 9001-certified SynNanoVect synthetic vector production platform, which brings together two teams of chemists and two teams of biologists and physicians. Another area is the development of peptides and peptidomimetics for applications in medicinal chemistry and materials.

PhD title

Doctorat de Chimie

Country where you obtained your PhD

France

Institution awarding doctoral degree

ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES

Graduate school

Matière, molécules, matériaux - 3M

Candidate's profile

We are looking for a motivated candidate with solid knowledge of organic synthesis and excellent theoretical and practical skills. Experience in peptide synthesis and/or HPLC and/or nanoparticle formulation will be appreciated but is not a prerequisite. We are looking for a researcher who is committed to his/her project, curious, with a degree of autonomy and rigour, and who is highly motivated. The candidate should also have good communication skills and be a team player.

2024-04-01
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