Permanent Researcher Position in Chemical Biology

The CEA is a world-class public research organization at the forefront of research, development, and innovation. SIMoS focuses on identifying and preclinical development of bioactive molecules, leveraging pioneering technologies in medical imaging, diagnostic advancements, and therapeutic innovations. At SIMoS’s Chemical Biology Laboratory (LBC), we push boundaries by developing innovative approaches to study native proteins in complex biological environments. Our team is making strides in ligand-directed chemistry, proximity labelling, and targeted proteolysis, laying the groundwork for new therapies in precision medicine.

As a permanent researcher in chemical biology, you will:

1. Expand ligand-directed chemistry to address a broader range of protein targets, both extracellular and intracellular.
2. Develop proximity labelling and targeted degradation strategies, including engineering proteases.
3. Innovate timing control methods for proximity labelling and protein degradation to enable precise applications in biological systems.

Your work will focus on different therapeutic targets to uncover novel insights into their physiological and pathological roles while contributing to transformative therapeutic strategies.

Organic chemist at the chemistry/biology interface, with 3 to 5 years of experience post-PhD.

• Knowledge of protein labeling approaches in complex environments.
• Familiarity with protein conjugation techniques.
• Proficiency in analytical methods for proteins: electrophoresis, gel imaging, mass spectrometry, and proteomics.

Key qualities: Rigor, organizational skills, and ability to work as part of a team