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3 years postdoc in cancer biology at the CNRS in Montpellier

ABG-82297 Job Junior
2019-01-11 Fixed-term 36 Month Salaire à négocier
CNRS UMR5237, CRBM
montpellier - Occitanie - France
Biology
Cancer Biology, cell signaling, tumor supressor, intestinal tumors, genetically modified mouse models
Research and Development

Employer

The CRBM is a leading research institute in biochemistry and cell biology in the south of France. It is located on a multidisciplinary campus of the CNRS in Montpellier. Research at the institute covers fundamental and translational aspects of biology, with focus on: cell division, adhesion and signaling, ene regulation and systems biology. It is composed of 16 research groups, bringing together 150 staff members and students. CRBM benefits from state-of-the-art platforms dedicated to imaging, proteomics, animal facilities, deep sequencing and transcriptomics, FACS sorting, and histology through the Montpellier BioCampus network.
The team "tyrosine kinase signaling and oncogenesis intends" to understand how the perturbation of tyrosine phosphorylation-dependent signalling promotes tumor formation and develop novel therapeutic strategy in human cancer from this research.

Position and assignments

Title: Deciphering SLAP tumor suppression function in colon cancer

Project: We wish to understand how the tyrosine kinase (TK) Src, which coordinate epithelial cell communication and fate decision, induce aggressive colon cancer. While Src is a well-defined oncogene in this cancer, this TK is rarely mutated and actually, the mechanisms promoting its cancer activity remain mysterious. During evolution, TK activities have become under the tight control of small adaptor proteins, which exert negative regulatory functions. We recently discovered that Src tumor activity is under the control of such a negative regulator, named SLAP. We propose that the expression of SLAP, which is reduced in 50% of the CRCs, defines a major mechanism for regulating the tumor activity of Src.

 Methodology: We will characterize the role of SLAP in homeostasis and intestinal epithelial tumor progression by employing genetically modified mice. The mechanism how SLAP is executing its anti-tumoral activity will be elucidated by combining sophisticated proteomic and molecular methods. Moreover, we will explore the role of SLAP in tumor response and resistance to targeted therapies, and finally evaluate the prognostic role of SLAP in patients with CRC.

Expected Outcomes: This project will decipher the tumor suppressing role of SLAP in CRC and thus pave the way for novel therapeutic and diagnostic strategies.

We seek a talented and motivated postdoc with a strong CV and a solid background in cancer biology and molecular and cell biology. 

3 years funding will be obtained through applications to coming ARC and FRM postdoctoral offers.

Geographic mobility:

National

Profile

highly motivated young postdoc (PhD otbained for less than 1 year) in molecular and cellular biology with a strong CV and a solid expertise in cancer biology.
PhD students that will defend their thesis in early 2018 may also apply.

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