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CDD post doctorant

ABG-93343 Job Any
2020-08-28 Fixed-term 12 Month > €35,000 and < €45,000 annual gross
Institut Curie
ORSAY - Ile-de-France - France
Biochemistry
  • Biology
  • Chemistry
ADN /ARN quadruplexe, protéines interactives, inhibition , agents anticancereux
2020-09-30
recherche

Employer

 

 

 

Institut Curie (IC) is a private non-profit foundation operating a research center on biophysics, cell biology and oncology and a hospital specialized in treatment of cancer. The Institut Curie is ranked at the top 1% of research institutes by IST. The Research Center of IC is one of the most important in Europe and the largest in France institutions dedicated to cancer research.. It houses about 80 joint research groups with CNRS (French national center for scientific research), INSERM (national center for medical research) or Universities. The common goal is to increase knowledge on cancer and ameliorate patient treatments using state-of-the-art technology platforms. Four big research domains (Genetics and Oncogenesis, Molecular Cell Biology, Chemical Biology and Life Physical Chemistry) have been defined with a view to improving prevention, diagnosis and treatment of cancer.

 

Work context:  The post-doctoral researcher will be part of the team “Probes and Drugs of Nucleic acids Secondary Structures” led by Dr. Teulade-Fichou in the laboratory “Chemistry and Modelling for the Biology of Cancer” (CMBC) located at Institut Curie, Orsay. The research activity of the team of MP Teulade-Fichou, at the interface between chemistry and biology, is mainly focused on targeting and imaging of nucleic acids, with a particular emphasis on non-canonical G-quadruplex (G4) DNA/RNA structures. The overall goals are i) to develop strategies and probes to image and map G4-interactive compounds distribution in cells and at the genome-wide level and ii) to explore the anticancer therapeutic potential of G4-interactive compounds. The team is multidisciplinary with complementary skills and expertise area spanning chemical biology and biochemistry to cellular biology and clinical research.

The candidate will benefit from the scientific environment of the Institut Curie (see link below) and will have access to the numerous technical platforms (chemical library, protein production, microscopy imaging, NGS etc..).

 

Position and assignments

Missions: He/she will develop a project to study the interactions between proteins and DNA or RNA secondary structures called quadruplexes (G4). A first part of the project will be devoted to biochemical and biophysical studies of the G4/protein interactions in vitro, a second part will be devoted to the exploration of G4/protein interactions in various cellular contexts, in particular in Epstein-Barr virus (EBV)-infected cancers cells. The details of the project will be directly discussed with the applicants. He/she will work under the direction of Dr. Marie-Paule Teulade-Fichou (CNRS Research Director, team leader and head of the CMBC Laboratory) in collaboration with other team members as part of the project supported by the Fondation pour la Recherche Médicale (FRM) in association with the teams of Anton Granzhan (junior team, CMBC / Institut Curie), Marc Blondel (INSERM / University De ) and Robin Farhaeus (INSERM, St. Louis Hospital, Paris).

Activities: The post-doctoral fellow will be in charge of developing his/her project. He/she will manage the design, plan, execute and interpret various experiments. He/she must master the associated literature, must be able to communicate his/her results to the team, the institute and the collaborators. He/she must be able to work independently as well as interact with other team members and collaborators.

Geographic mobility:

European

Starting date

2020-10-31

Profile

Skills: We are looking for a highly motivated and dynamic scientist. The candidate must hold a Ph.D. degree in the fields of Biochemistry, Biophysics or Molecular and Cellular Biology, with an excellent knowledge of nucleic acid structures and protein/nucleic acid interactions. Hands-on experience with state-of-the-art biochemical and biophysical techniques for studies of protein/nucleic acid interactions in vitro and in cellulo as well as cellular imaging are required. The candidate must be an author or co-author of at least one publication related to the subject or skills required for the project. Applicants must be able to fluently communicate in English (oral and written skills).

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