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Postdoctoral position in organic synthesis, IBMM, Montpellier FRANCE

ABG-100504 Emploi Confirmé
11/10/2021 CDD 13 Mois > 45 et < 55 K€ brut annuel
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Institut des Biomolécules Max Mousseron
Montpellier - Occitanie - France
Chimie
Synthèse organique, méthodologie, synthèse peptidique, SPPS
29/10/2021
Recherche et Développement

Employeur

We are looking for highly motivated and creative postdoc to join the Department of Amino Acids, Peptides and Proteins, Montpellier (France) in the Peptide team (www.ibmmpeptide.com). The IBMM-Peptide research group belongs to the Institute of Biomolecules Max Mousseron. The Institute of Biomolecules Max Mousseron Biomolecules (IBMM, Université de Montpellier, CNRS, ENSCM), is an international research establishment belonging to Pole Chimie Balard (600 researchers in chemistry, 80 postdoc and 50 PhD/year). The research activities of the IBMM are located at the interface of chemistry and biology, they aim to study and understand the mechanisms of action of biomolecules for the treatment of pathologies. IBMM already designed two marketed drugs and is interested by the design, the synthesis and biological studies of bioactive compounds and materials. IBMM is specialized in essential biomolecules : lipids, nucleosides, nucleotides and nucleic acids, peptides and proteins, glycosides, biopolymers.

Poste et missions

Your mission will be to study the transposition of an original procedure for the formation of amide bonds based on the activation of the amine group, using SPPS (solid phase peptide synthesis).

Context of the project: Peptides and proteins are essential biomolecules to sustain life, implicated in almost all physiological processes. While peptides are biosynthetically built up from the N→C direction, they are chemically synthesized on the opposite direction (C→N). Indeed, the traditional amide bond formations involve the use of complex and expensive coupling reagents in order to activate the carboxylic acid moiety of a first amino acid (AA) allowing the nucleophilic attack of the amino partner of a second AA. Although very efficient, these strategies suffer from several drawbacks inherently linked to the activation mode of these coupling reagents. In 2014, the team of Prof. J.M Campagne and Dr R. Marcia de Figueiredo (ICGM, Montpellier) proposed an original procedure for the formation of amides on the basis of a novel mode of activation (Angew. Chem. Int. Ed., 2014, 53, 5389-5393). This “inverse activation” proceeds through the modification of the α-amine function instead of classical carboxylate activation of AAs. In close collaboration with this team, the project consists to explore a whole range of unprecedented possibilities offered by this new mode of activation and to challenge the paradigm of the peptide synthesis (amino vs carboxyl activation; e.g. N→C direction). In particular, the transposition of this new mode of activation will be studied on solid support.

Mobilité géographique :

Pas de déplacement

Prise de fonction :

01/12/2021

Profil

Candidates should have a PhD and strong skills in organic chemistry; An experience in peptide synthesis and SSPS is not required but will be appreciated.

 

 

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