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Postdoctoral research position : Antiviral Immunity - Innovative therapy

ABG-101407 Emploi Niveau d'expérience indifférent
29/11/2021 CDD 30 Mois > 55 et < 75 K€ brut annuel
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Research Center for Respiratory Diseases, Inserm U1100
TOURS - Centre Val de Loire - France
Biologie
  • Santé, médecine humaine, vétérinaire
influenza - virus - SARS-CoV-2 - antiviral - immunity - cell signaling - therapy
29/04/2022
Recherche et Développement

Employeur

Respiratory diseases have a significant impact from a medical and socioeconomic viewpoint. The World Health Organisation (WHO) classifies pneumonia among the ten leading causes of death worldwide.

Despite this critical situation, the existing treatments are limited as they relieve some symptoms, but are seldom curative. These data underscore the urgent need to develop innovate research with the aim of achieving a better understanding of the pathophysiology of respiratory diseases and formulating more effective devices for targeted therapy. This is precisely the missions that the Research center for Respiratory Diseases ("CEPR") has set itself, aided by the numerous complementary resources and expertise existing within its 3 research teams.

Poste et missions

Context: Respiratory viral infections remain one of the top global causes of death and the emergence of new virus strains (influenza A virus, SARS-CoV-2,...) continues to be a major concern. Efficient drugs against coronaviruses are very limited and the efficacy of drugs targeting influenza virus is largely disputed. Hence, the development of innovative antiviral drugs is required to better treat influenza virus as well as SARS-CoV-2 pneumonia.

The postdoc fellow (F/M/D) will contribute to a 30 months research program that will help to ultimately develop an innovative host-directed antiviral therapy that will be administered via the pulmonary route.

Our original approach is based on our recent evidence that endogenous metabolites are pivotal effectors of the host antiviral immune response (EMBO J., in revision).

The successful candidate will join an interdisciplinary and collaborative team working with three other partners (from CNRS-Université Paris-Saclay and Anses-Ecole Nationale Vétérinaire d'Alfort) The postdoctoral fellow will be involved in regular scientific interactions/meetings with these collaborating labs.

Location: INSERM unit 1100, Research Center for Respiratory Diseases, team: "respiratory infection & immunity", Faculty of medicine, Tours, France.

The host lab benefits from state-of-the-art technological facilities for cell culture, flow cytometry, cell and molecular biology, microscopy and animal studies.

The host lab is a dynamic research team including researchers, lecturers, clinicians, technicians, postdocs and students.

Mobilité géographique :

Nationale

Profil

Requirements: Highly motivated candidates (F/M/D) with a proven track record of scientific accomplishments are encouraged to apply.

Applicants should hold a PhD or a MD/PhD degree in Immunology or Virology. Expertise in cell culture and mouse vivo models is necessary. 

Previous hands-on experience on virology and immunological techniques will be ideal. Experience in medicinal chemistry will be also a plus. Good communication skills are essential in English.

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