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Postdoctoral A. Computational Biology Clinical NGS analysis

ABG-101807 Emploi Confirmé
14/12/2021 CDD 18 Mois > 45 et < 55 K€ brut annuel
Logo de
Servier
Boston - Etats-Unis d'Amérique
Santé, médecine humaine, vétérinaire
Recherche et Développement

Employeur

Servier is a global pharmaceutical group present in 150 countries and employing 22, 500 people worldwide. Commited to accelerate therapeutic innovation to serve patients, the Servier Group focuses on cardiovascular and metabolic diseases, oncology, neuropsychiatric and venous diseases. In 2020, the Servier Group achieved a revenue of 4.7 billion in 150 countries.

Whatever your area of expertise, your work within the Servier Group will help advance therapeutic progress to serve patient needs. At Servier, you'll be part of teams recognized for their scientific excellence. Ready to build the healthcare of tomorrow, they share strong fundamental values: care, dare to innovate, commit to succeed, grow by sharing.

Servier is certified Top Employer Europe 2021.

 

Poste et missions

Main Focus and Challenges

The postdoctoral candidate will conduct analyses of next-generation sequencing data from ivosidenib and vorasidenib clinical trial biopsy samples.

Key responsibilities

  • Evaluation of genetic variability using RNAseq data from clinical samples
  • Assessment of alternative splicing and possibly gene fusions from exome-capture RNAseq data
  • Analysis of mutational signatures, MSI, and tumor mutational burden in cancer panel DNAseq data from clinical samples without matched germline samples
  • Apply the above technologies to data from the ivosidenib and vorasidenib clinical trials, with the goal of delivering potential biomarkers and combination strategies to the programs
  • Publish both the technological and biological findings from this work

Le Groupe Servier s'engage pour la diversité et le respect de la législation dans le cadre de ses recrutements.

At Servier, we are committed to therapeutic progress to serve patient needs. We put the diversity of our employees as a source of richness for the fulfillment of this vocation.

Mobilité géographique :

Nationale

Profil

IDEAL PROFILE

Qualifications

  • Ph.D. in Computational Biology, Biology, Statistics, or a related field

Professional experience

  • Experience translating Bioinformatics analysis results into new biological insights, propose next experiments, and enable program decisions
  • Experience in processing and analysis of next-generation sequencing data (RNA, DNA, and/or DNA methylation)
  • Hands-on experience with data visualization tools (Plotly, R-Shiny, Dash, Spotfire, etc).
  • Working experience in Translational Science and handling of patient genomic data is preferred
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