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Post-doctoral position in Leukemia Research

ABG-101960 Emploi Confirmé
13/01/2022 CDD 24 Mois > 55 et < 75 K€ brut annuel
Logo de
Luxembourg Institute of Health
Luxembourg - Luxembourg
Biologie
Cancer research, leukemia
28/02/2022
Recherche et Développement

Employeur

The Luxembourg Institute of Health (LIH) is a public biomedical research organization focused on precision health and invested in becoming a leading reference in Europe for the translation of scientific excellence into meaningful benefits for patients.

LIH places the patient at the heart of all its activities, driven by a collective obligation towards society to use knowledge and technology arising from research on patient-derived data to have a direct impact on people’s health. Its dedicated teams of multidisciplinary researchers strive for excellence, generating relevant knowledge linked to immune related diseases and cancer.

The institute embraces collaborations, disruptive technology and process innovation as unique opportunities to improve the application of diagnostics and therapeutics with the long-term goal of preventing disease

Poste et missions

Background. Chronic Lymphocytic Leukemia (CLL) represent the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is characterized by an accumulation of abnormal, apoptosis- resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on complex interactions between tumour cells and their microenvironment. Indeed, CLL cells can modify stromal cells and immune cells to promote their survival and to escape from the immune surveillance system.

Objectives. Our team focuses on the mechanisms leading to leukemia progression, in particular the influence of CLL cells on stromal cells and immune cells located in their microenvironment, with the goal to identify new prognostic markers and therapeutic targets.

Training and research environmentTumour Stroma Interactions research group is a dynamic and multinational team whose current members originate from France, Belgium, Luxembourg, Spain, Germany, Italy and Argentina. It belongs to the Department of Cancer Research, whose research activities focus on the cellular and molecular mechanisms of tumour progression using a wide range of cutting edge technologies, including genomic, transcriptomic and proteomic analyses, as well as in vitro and in vivo imaging modalities using state-of-the-art animal models for cancer research. The post-doctoral researcher will be working on a large FNR CORE-funded project that aims to explore the complex interplay between CLL cells and immune cells in the microenvironment, and will be co-supervised by Dr  E. Moussay (PI) and Dr  J. Paggetti (PI).

Recent related references (open access): Paggetti J, et al. Exosomes released by chronic lymphocytic leukemia cells induce cancer-associated fibroblast formation. Blood 126(9):1106-17.

Wierz M, et al. Dual PD1/LAG3 immune checkpoint blockade limits tumour development in a murine model of chronic lymphocytic leukemia. Blood 131(14):1617-1621. (IF:23.8).

 

More information about the group can be found here : https://tsi.lih.lu

 

2-year fixed-term contract, full time. Annual gross salary: 60k€. Start date: from February 2022

 

The applicants should submit below before 28 February 2022 a letter detailing their motivation and a curriculum vitae with the ref. : VD/PDR1221/JPEM/TSI

 

Mobilité géographique :

Pas de déplacement

Télétravail :

Occasionnel

Prise de fonction :

15/02/2022

Profil

  • PhD in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage.
  • Experience in cell culture, biochemistry, molecular biology, imaging, flow-cytometry, and mouse experimentation techniques required.
  • Animal experimentation diploma (FELASA or equivalent) would be considered as an asset.
  • Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills,  sense of priority and ability to work with others.

Fluency in English is mandatory

Objectifs

Faire avancer le groupe de recherche sur cette thématique et publier.

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