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Postdoctoral research fellow in synthetic Organic Chemistry

ABG-102231 Emploi Niveau d'expérience indifférent
10/01/2022 CDD 24 Mois > 25 et < 35 K€ brut annuel
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UMR 6014-COBRA CNRS
Mont-Saint-Aignan - Normandie - France
Chimie
Organic chemistry, peptides crosslinking, trifunctional reagent
Recherche et Développement

Employeur

Location: COBRA, UMR 6014, CNRS, Rouen Normandy University, France.  team: “Bioorganic Chemistry”

Scientific supervisors: Dr. Cyrille Sabot & Prof. Pierre-Yves Renard

Poste et missions

PROJECT: Understanding key molecular mechanisms of infectious diseases is the first step towards the development of vaccines and treatments. One critical step of the infection processes is the interaction between the pathogen and its target host cells. Dissecting this interaction at the molecular and thus protein level is therefore of the utmost importance.
A number of chemical ligation tools (crosslinkers) have been reported to irreversibly trap weak and transient protein interactions and allow detailed mapping of interaction interfaces by LC-MS-MS. These tools are generally divided into two classes according to their ability to react either with specific residues (Lysine or Cysteine) or with any nearby residues regardless of their nature (Anal Chem, 2015, 87, 1853-60). Whilst these strategies are particularly effective for in vitro applications, the complexity of the crosslinked peptide mixture to be analyzed by LC-MS-MS is dramatically increased by the presence of two distinct biological organisms raising the technological challenge to a new limit. This project carried out in collaboration with the Pasteur Institute in Paris, will aim at developing a next generation of crosslinkers to facilitate the identification of crosslinked peptides for in vivo applications.

Mobilité géographique :

Internationale

Télétravail :

Impossible

Profil

- Excellent skills in organic synthesis or synthetic methodology. An interest in working at the interface between chemistry and biology would be an advantage

‐ Strong communication and leadership skills

 

 

 

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