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Repurposing of FDA-approved drugs promoting oligodendrogenesis for brain injury of the preterm

ABG-107048 Sujet de Thèse
05/08/2022 Financement public/privé
INSERM U1208
Bron - Auvergne-Rhône-Alpes - France
Repurposing of FDA-approved drugs promoting oligodendrogenesis for brain injury of the preterm
  • Biologie
  • Psychologie, neurosciences
neural stem cells, postnatal brain injuries, cellular repair

Description du sujet

Project: Preterm-birth brain injury (PBI) is a major public health concern, with many surviving children developing cognitive and neuropsychiatric deficits. The developmental period around birth is a time of active generation of oligodendrocytes, myelination, and axonal reorganization that is strongly perturbed in many preterm-born children.  Through a pharmacogenomics analysis based on the generation and expert curation of transcriptomic datasets, we identified novel small bioactive molecules fostering oligodendrogenesis by acting on transcriptional programs underlying their proliferation or maturation. In this project, we will use cutting edge histological and transcriptional approaches to 1) dissect out the mode of action of these molecules, 2) investigate their potential effects on other lineages than oligodendroglia. This project, supported by the ANR (Project NeoReGen), and involves a close collaboration with the Parras team (ICM, Paris) and Gressens team (Diderot Hospital, Paris). For more background, see Azim et al., Plos Biol 2017, Donega et al., Cell Reports 2018, Marie C et al., PNAS, 2018.

 

 

Prise de fonction :

01/11/2022

Nature du financement

Financement public/privé

Précisions sur le financement

ANR

Présentation établissement et labo d'accueil

INSERM U1208

Environment: You will join a multidisciplinary team of scientists. The SBRI benefits from state-of-the-art research platforms including Omics and Imaging, and provide a high-quality scientific, technological and medical environment.

Intitulé du doctorat

PhD in Neurosciences

Pays d'obtention du doctorat

France

Etablissement délivrant le doctorat

UCBL

Ecole doctorale

Biologie moléculaire, intégrative et cellulaire (BMIC)

Profil du candidat

Candidates: We are looking for an enthusiastic and highly motivated scientist holding a M2 in neurosciences or cellular biology and willing to join a challenging research area. Experience in histology and bioinformatic analysis/scripting would be valuable. Strong communication skills, team spirit and ability to work in a multidisciplinary team are expected.

30/09/2022
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