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Long-term consequences of early metabolic brain insults on cortical networks organization and functional integrity

ABG-107049 Sujet de Thèse
05/08/2022 Financement public/privé
INSERM U1208
Bron - Auvergne-Rhône-Alpes - France
Long-term consequences of early metabolic brain insults on cortical networks organization and functional integrity
  • Biologie
  • Psychologie, neurosciences
Postnatal brain injuries, energy metabolism, brain wiring, repair

Description du sujet

Project: This project is built on the unique expertise of our teams in postnatal brain development (Olivier Raineteau) and energy metabolism during neuron development (Julien Courchet) to unravel the consequences of premature brain injuries on circuits formation. This project, supported by the ANR (Project Rewired), aims at testing the hypothesis that alterations of the metabolic homeostasis during the critical period of plasticity leave a “metabolic scar”, leading to long-lasting alterations of the organization and function of neural circuits.  For more background, see Azim et al., Plos Biol 2017, Donega et al., Cell Reports 2018, Courchet et al., Nat Commun, 2018.

Prise de fonction :

01/11/2022

Nature du financement

Financement public/privé

Précisions sur le financement

ANR

Présentation établissement et labo d'accueil

INSERM U1208

Environment: You will join a multidisciplinary team of scientists. The SBRI benefits from state-of-the-art research platforms including Omics and Imaging, and provide a high-quality scientific, technological and medical environment. The project will involve a close collaboration with the Courchet team in Lyon (INMG, Lyon).

Intitulé du doctorat

PhD in Neurosciences

Pays d'obtention du doctorat

France

Etablissement délivrant le doctorat

UNIVERSITE CLAUDE-BERNARD-LYON 1

Ecole doctorale

Biologie moléculaire, intégrative et cellulaire (BMIC)

Profil du candidat

Candidates: We are looking for an enthusiastic and highly motivated scientist holding a M2 in neurosciences or cellular biology and willing to join a challenging research area. Experience in histology and bioinformatic analysis/scripting would be valuable. Strong communication skills, team spirit and ability to work in a multidisciplinary team are expected.

30/09/2022
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