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PhD student in Nutrition and Health

ABG-109247 Sujet de Thèse
24/11/2022 Contrat doctoral
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Luxembourg Institute of Health
Strassen - Luxembourg
PhD student in Nutrition and Health
  • Biologie

Description du sujet

Background. Secondary plant metabolites have been related to a number of chronic diseases. Among these, carotenoids are the most frequently consumed lipophilic phytochemicals. However, their bioavailability, i.e. the fraction that can be absorbed and used for physiological functions is rather low and variable. Their release from the food matrix during digestion is among the crucial steps determining bioavailability. Especially dietary fibers have been reported to interact with the release and cellular uptake of carotenoids, but their effects have not been studied systematically. Their interactions with other macronutrients (proteins and lipids) and their interactions with the gut microbiota are not understood either.

Objectives. This is a 3+1-year project funded by the FNR. It is part of a larger project investigating interactions of dietary fibers and carotenoids during digestion. The main aims are to 1) study the effect of dietary fibers during simulated in vitro gastro-intestinal digestion on carotenoid bioaccessibility (involving HPLC, UV-Vis, rheological aspects); 2) investigate interactions between dietary fibers and macronutrients regarding their effect on carotenoid bioavailability aspects, including cellular uptake (Caco-2 cells, co-cultures), 3) investigate bacterial break-down products (LC-MS/MS); 4) study their impact on gut microbiota models (batch fermentation, SHIME model); 4) conduct a human clinical postprandial trial to study the effect of various dietary fibers on carotenoid absorption (from planning to carry-out).

Training and research environment The Nutrition and Health Research Group is a dynamic and multinational team belonging to the Department of Precision Health. The Nutrition and Health Research Team works at the intersection of basic research and nutritional epidemiology with a focus on translational aspects to improve population health.

We leave some flexibility to incorporate the candidate's own ideas in order to further study the interactions of dietary fibers, other nutrients and carotenoid bioavailability aspects. The project has been fully funded and should commence on May 1st, 2023 at the latest.

This project will be co-supervised by Dr. Torsten Bohn & Dr. Farhad Vahid.

What we offer

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program, and the possibility for close collaborations with universities and other research institutes.

A competitive salary with full benefits will be offered.

Professional profile of the group leader & activities: Dr Torsten Bohn

 

Prise de fonction :

01/05/2023

Nature du financement

Contrat doctoral

Précisions sur le financement

Présentation établissement et labo d'accueil

Luxembourg Institute of Health

The Luxembourg Institute of Health (LIH) is a public biomedical research organisation focused on precision health and invested in becoming a leading reference in Europe for the translation of scientific excellence into meaningful benefits for patients. LIH places the patient at the heart of all its activities, driven by a collective obligation towards society to use knowledge and technology arising from research on patient-derived data to have a direct impact on people’s health. Its dedicated teams of multidisciplinary researchers strive for excellence, generating relevant knowledge linked to immune related diseases and cancer. The institute embraces collaborations, disruptive technology and process innovation as unique opportunities to improve the application of diagnostics and therapeutics with the long-term goal of preventing disease.

Intitulé du doctorat

Doctorat en Biologie

Pays d'obtention du doctorat

Luxembourg

Etablissement délivrant le doctorat

Université du luxembourg

Profil du candidat

KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
  • Master (degree obtained before May 1st, 2023) with a background/education in nutrition, biochemistry, biology, molecular chemistry or equivalent.
  • Hands-on laboratory experience, preferably on cell lines, bacteria and/or other analytical aspects is essential.
    Knowledge on digestion and/or gut microbiota, as well as statistics, are assets.
  • Excellent time management, rigour, perseverance, scientific creativity and originality,  sense of priority and ability to work in a Team.
  • Fluency in English and excellent writing skills are mandatory.
15/01/2023
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