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Postdoctoral position at the Pasteur Institute, Paris: Role of T cell responses in Long COVID

ABG-113946 Emploi Confirmé
28/04/2023 CDD 36 Mois > 35 et < 45 K€ brut annuel
Institut Pasteur
Paris - Ile-de-France - France
Immunology, T cells, single cell, TCR, microfluidics, SARS-CoV-2
Recherche et Développement


The Institut Pasteur, based in Paris, France, is an international research institute with a mission to help prevent and treat diseases, mainly those of infectious origin. These issues are addressed by around 2,900 people working side by side on the Paris campus. This includes over 1,500 scientists (researchers, engineers, students), within 12 departments and 144 research units. This major hub of activity facilitates collaboration between colleagues in the different laboratories and fosters interdisciplinary approaches. Teams have access to technological hubs and platforms that provide access to state-of-the-art technology and biocomputing resources.


Poste et missions

A post-doctoral position is available to study the immune mechanisms involved in Long COVID. The successful applicant will join the team of Lisa Chakrabarti at the Pasteur Institute in Paris. The position is funded for 3 years by the ANRS-MIE.


A significant proportion of patients with COVID-19 still experiences symptoms more than 3 months after an initial infection with SARS-CoV-2. Persisting or reemerging symptoms are varied, with a predominance of asthenia, neurocognitive impairment, and dyspnea. The persistence of these debilitating symptoms defines the Long COVID syndrome, which is now considered a serious public health concern. Importantly, the etiology of Long COVID remains unknown. We propose to test the hypothesis that an inefficient antiviral T cell response underlies Long COVID. The rationale is that suboptimal T cell immunity could promote viral persistence, with residual virus in turn causing localized tissue damage and persistent inflammation.


The study will involve an in-depth analysis of SARS-CoV-2 specific T cell responses in Long COVID patients and convalescents, based on spectral flow cytometry analyses on previously collected blood samples. The repertoire of SARS-CoV-2-specific T cell receptors (TCRs) will be compared between groups by single cell approaches. The efficiency of the T cell response will be evaluated at the molecular level, by analyzing the affinity of the most prevalent TCRs specific for immunodominant SARS-CoV-2 epitopes. CD4+ T cell/ B cell interactions will be evaluated in a novel lymph-node-on-chip system, to explore why a subset of Long COVID patients do not seroconvert. Clinical evaluation and sensitive ddPCR viral load measurements will be performed by collaborating teams. An integrated analysis of these parameters will help determine whether inefficient T cell responses correlate with residual inflammation and viral persistence. The postdoctoral fellow will benefit from the availability of biobanked samples, the access to state-of-the art technological platforms, and the very dynamic environment of the Pasteur Institute.

Mobilité géographique :

Pas de déplacement


We are looking for a skilled and highly motivated candidate with:
• a PhD in the field of Immunology or Virology,
• research experience in the analysis of T cell responses and/or spectral flow cytometry
• a strong motivation to learn single cell technologies
• a track record of publications in relevant scientific fields
Expertise in cell sorting will be an asset. The ability to work independently and good communication skills in spoken and written English will be essential.

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