Postdoctoral position in ion channel function

The University of Lausanne is composed of seven faculties with approximately 15,300 students and 3,000 researchers. The University of Lausanne is focused on several academic disciplines, especially Medicine, Life Sciences, Geosciences, Environment, Business, Humanities and Social Sciences.

A postdoctoral position, funded by the Swiss National Science Foundation, is available in the laboratory of Stephan Kellenberger at the Department of biomedical Sciences (DSB) of the University of Lausanne. Our laboratory works towards a molecular understanding of the activation mechanisms of the "acid-sensing ion channels"(ASICs). ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Kellenberger and Schild, Pharmacol Rev 67: 1-35, 2015). The postdoctoral fellow will investigate the ASIC activation mechanism with functional approaches, based on predictions from high-resolution structures and from Molecular Dynamics simulations. To this end, she/he will analyze Molecular Dynamics data and use electrophysiological and fluorescent approaches on mostly recombinantly expressed ASICs.

For further information, please consult the following publications that illustrate our approaches:

Molton O, et al., 2024. Open biology 14: 240028, 10.1098/rsob.240028

Vullo S et al., 2021. eLife 10, 10.7554/eLife.66488 

We are a small, dynamic and motivated team. The position is for 18 months. The DSB, with 18 research teams, offers a stimulating and competitive research environment in modern biology with multidisciplinary expertise (www.unil.ch/dsb). Lausanne, with its university and the EPFL is a center of life science research.

Contact: Prof. Stephan Kellenberger, Département de Sciences biomédicales, Université de Lausanne, Rue du Bugnon 27, CH-1011 Lausanne, https://wp.unil.ch/kellenberger-lab/

We are looking for a talented and motivated postdoctoral researcher. Applicants need to have a PhD in life sciences or a related domain. They must have relevant experience with electrophysiology (patch-clamp or two-electrode voltage-clamp) and fluorescence approaches, and ideally be familiar with the analysis of protein structures. Additional desired qualifications are a basic knowledge of molecular biology and biochemistry.