POST-DOC FELLOW IN IMMUNOLOGY & 3D BIOPRINTING

The post-doctoral fellow will be recruited within the framework of Print@Lung, a consortium funded by ShapeMed@Lyon.

The Print@Lung project was funded by the ShapeMed@Lyon program, coordinated by univ-Lyon1. The aim of this project is to propose a new in-vitro model of 3D-printed lung tissue. This collaborative project is led by Fabienne Archer (IVPC laboratory), Emma Petiot (3d.FAB platform) and Karen Moreau (CIRI StaphPath team).

The research work will be mainly hosted in 3d.FAB platform, an innovative technological platform of Lyon university.  3d.FAB platform is specialized in academic and private innovations through 3D printing and bioprinting in the field of life science and healthcare. 3d.FAB owns 170 m² of laboratory to welcome the bioprinting, bioprocesses and regenerative medicine activities. 

The Print-a-Lung project is recruiting a post-doctoral fellow in tissue engineering and immunology, to add complexity to the bioprinted lung model already established within the consortium. The aim is to bring in the immunological component and a complex regionalization/architecture of the respiratory tract to mimic respiratory host-pathogen interactions in a more relevant way.

Scientific mission: The highly motivated post-doc will develop methods for inserting the immune compartment into a pre-established bioprinted lung model. This will involve selecting populations of immune cells from lung tissue (extraction/selection) and proposing bioprinting strategies (micro-extrusion, inkjet) and monitoring the behaviour of the different cell types, under control conditions and in response to stress (infectious or environmental). The mission will be carried out in collaboration with the various partners in the ShapeMEd Print-a-Lung project, including bioprinting specialists, specialists in lung biology as well as in lung pathologies. Part of the activity will also focus on the regionalisation and 3D structuring of bioprinted tissues. 

Administrative tasks: The post-doc will be involved in coordinating the project with the project's 3 co-leaders. In particular, he/she will be involved in communication and setting up and updating the project's DMP.

Profile required:

Expected skills in tissue bioengineering, immunology or pulmonary physiology/physiopathology: Culture of immune cells within biomaterials; Characterization/stimulation of immune cells (ideally from lung tissue); Culture and cell and tissue biology (work in sterile conditions, classic cell characterization tools i.e. cytometry, IF, Elisa, Histology etc.); Immunology (ideally from lung mucous membranes); Cell and tissue biology (work in sterile conditions, classic cell characterization tools i.e. cytometry, IF, Elisa, Histology etc.).

Knowledge in one of these areas: Cell and tissue biology (ideally of lung); Immunology (ideally of pulmonary mucosa), Immune cell / biomaterial interaction, Experience in 3D printing / bioprinting would be a plus

Specific software or equipments used: CAD / 3D bioprinters / Cytometry / Confocal microscopy / Histology / Cell culture

Skills: Teamwork - multi-partner project; enthusiastic and dynamic, Good level of English. 

Diploma required: PhD, Doctorate in Science

Level of experience required: between 1 and 3 years