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Role of p53 isoforms in cancer cell invasion of colorectal cancer

ABG-74233 Emploi Niveau d'expérience indifférent
07/12/2017 Intérim > 35 et < 45 K€ brut annuel
CNRS
Montpellier - Occitanie - France
  • Biologie
migration, p53, colorecatl cancer, invasion, metastasis
Recherche et Développement

Employeur

CRBM is among the world’s leading provider of innovative research in cancer field and is closely affiliated with the University of Montpellier and the CNRS. The CRBM enjoys a dynamic and international life annimated by weekly seminars and high-level meetings.

Poste et missions

Our project is focused on the p53 tumor suppressor gene, the most frequently mutated gene in all cancer types. We have recently highlighted the role of alternative splicing in p53 regulation, demonstrating a crucial role of p53 isoforms in the regulation of cell invasion and metastasis. The p53 gene produces a complex profile of alternatively spliced transcripts and can generate at least twelve protein isoforms. The team recently showed that the Δ133p53ß isoform constitutes a biomarker of shorter disease-free survival for patients suffering from breast or rectal cancer. This isoform controls cancer stem cell potential, cell invasion, EMT and metastasis. These properties are independent of p53 mutation status. For more information on the Team, visit our web page

Mobilité géographique :

Internationale

Prise de fonction :

01/02/2018

Profil

Candidate requirements:

  • We welcome applications from scientists in cell biology and cancer biology.
  • The candidate has a PhD in cancer biology (with or without post-doc experience). He/she must have expertise in high-throughput RNA sequencing data and experience in standard molecular and cell biology technique. The successful candidate will identify mechanisms that lead to invasion and metastasis.
  • We are searching for a postdoc fellow who can work independently and develop his/her own ideas and visions in line with the project. Candidates should be highly motivated, creative, and have strong communication skills. The ability to communicate in English at a high level, interact effectively and work productively in a team will be considered important.

 

 

Objectifs

 The candidate will be involved in two main objectives: unravel the signaling that produces Δ133p53ß and identify the mechanisms by which this isoform exerts is pro-invasive activity.

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