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Senior Research Scientist: High-throughput Protein Engineering

ABG-74689 Emploi Confirmé
12/01/2018 CDI > 35 et < 45 K€ brut annuel
Logo de
PMC Isochem
Vert-Le-Petit - Ile-de-France - France
  • Biochimie
  • Biotechnologie
  • Chimie
high-throughput, Protein Engineering, Biochemistry, Molecular Biology, Chemical Engineering,
Recherche et Développement

Employeur

PMC Isochem is a new company of the PMC Group. PMC Isochem operates a fully integrated business comprised of research, product/process development, regulatory approvals, pilot scale and full plant-scale production of drug intermediates and active pharma ingredients (APIs) for major pharmaceutical companies worldwide to serve the needs of Oncology, Cardiovascular, Infectious, Gastro-Intestinal, Neurology and rare diseases. The facilities are all cGMP US-FDA audited plants for manufacturing pharmaceutical products.

About PMC Group:  PMC Group is a global chemicals and pharmaceutical conglomerate headquartered near Philadelphia, with research and manufacturing facilities spanning across the U.S., Europe, and Asia. Its annual revenue is close to $1 billion and the company is 100% owned by the Chakrabarti Family.  Several of PMC Group’s subsidiaries were previously subsidiaries of leading global corporations, including BASF, AkzoNobel, Dow, ICI, Arkema, PPG Industries, ExxonMobil, and France’s SNPE. PMC Group’s pharmaceutical division – which spans locations in New Jersey; Paris, France; and Hyderabad, India -- is comprised of research, product/process development, regulatory approvals, pilot scale and full plant-scale production of drug intermediates and active pharma ingredients (APIs).

About PMC Advanced Technology: PMC Advanced Technology (PMC-AT) is the technology development and basic research arm of PMC Group, Inc, and is comprised of Divisions of Fundamental and Applied Research. PMC’s Director of Research, Dr. Raj Chakrabarti (AB Harvard, PhD Princeton), is the founder of PMC-AT and was formerly Professor of Chemical Engineering at Purdue University and then Carnegie Mellon University. PMC-AT’s research focuses on the application of systems engineering methods to molecular engineering problems ranging from high-throughput enzyme design to the control of quantum molecular dynamics. Senior research positions at PMC-AT include the opportunity to publish research results in peer-reviewed journals. Some of the journals our group has published in include The Journal of Chemical Physics, Physical Review, Biophysical Journal, PNAS, and Plos One. Intellectual property developed at PMC Advanced Technology is commercialized by PMC Group and its affiliates. Intellectual property previously developed by PMC-AT scientists has been licensed by companies including New England Biolabs, Celera Diagnostics, Quest Diagnostics, and Abbott. 

 

 

 

Poste et missions

Background: PMC Advanced Technology, LLC (PMC-AT) is currently seeking several senior researchers in the area of high-throughput protein engineering to lead discovery efforts that constitute an important part of PMC Group’s pharmaceutical growth initiatives.

Qualifications: PhD in Chemistry, Biochemistry, Molecular Biology, or Chemical Engineering; with PhD or post-PhD experience focused on high-throughput protein engineering or other high-throughput genetic selection methods; some postdoctoral experience preferred

Responsibilities: Supervise a team working on the application of high-throughput protein engineering techniques, including modern methods of directed evolution, to systems including industrial enzymes, enzymes for DNA biotechnology, and peptide drugs. The methods include generation and screening of protein libraries using a variety of techniques. The methods for generation of protein libraries include the production of mutations at individual amino acid positions, production of random mutations, and production of combinatorial libraries of mutations in predefined regions of the protein. The methods for screening and selection include survival-based growth assay selection, microplate-based fluorescence screening, fluorescence-activated cell sorting, cell surface display, real-time PCR, and microemulsion droplet selection.

Compensation: Commensurate with experience; competitive with senior scientist positions at top pharmaceutical companies

Mobilité géographique :

Internationale

Profil

Qualifications: PhD in Chemistry, Biochemistry, Molecular Biology, or Chemical Engineering; with PhD or post-PhD experience focused on high-throughput protein engineering or other high-throughput genetic selection methods; some postdoctoral experience preferred.

Background: PMC Advanced Technology, LLC (PMC-AT) is currently seeking several senior researchers in the area of high-throughput protein engineering to lead discovery efforts that constitute an important part of PMC Group’s pharmaceutical growth initiatives.

Objectifs

Responsibilities: Supervise a team working on the application of high-throughput protein engineering techniques, including modern methods of directed evolution, to systems including industrial enzymes, enzymes for DNA biotechnology, and peptide drugs. The methods include generation and screening of protein libraries using a variety of techniques. The methods for generation of protein libraries include the production of mutations at individual amino acid positions, production of random mutations, and production of combinatorial libraries of mutations in predefined regions of the protein. The methods for screening and selection include survival-based growth assay selection, microplate-based fluorescence screening, fluorescence-activated cell sorting, cell surface display, real-time PCR, and microemulsion droplet selection.

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