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PhD Student in Epigenetics

ABG-75414 Sujet de Thèse
13/02/2018 > 35 et < 45 K€ brut annuel
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Luxembourg Institute of Health
Esch sur Alzette - Luxembourg
PhD Student in Epigenetics
  • Biochimie
  • Biologie
DNA methylation, diabetes, epigenotypes, epigenetics, Genetics, Molecular biology

Description

In the context of the FNR / ANR (France) funded project “MADAM”, addressing the pathomechanisms underlying comorbid depression and diabetes, Dr Jonathan Turner, PI Immune Endocrine Epigenetics Research group, is looking to recruit a PhD Student in Epigenetics.

Project

Type 2 Diabetes (T2D) and depression often occur together, and there is increasing evidence that they share pathophysiological and mechanistic origins, particularly based in inflammatory cytokine-mediated innate immunity, and/or the hypothalamus-pituitary-adrenal axis.

Epigenetic processes such as DNA methylation integrate the environment and inherited traits to predispose individuals to diseases. For T2D and depression, the evidence is growing that disease loci are epigenetically regulated, and that epigenotypes may be transmitted from one generation to the next and play a significant role in disease development. This PhD Student position, in the Immune Endocrine Epigenetics Research Group, aims to unravel the mechanisms underlying the link between T2D and depression in preclinical epigenetic models of non-obese T2D. Additionally, we will identify the contribution of epigenetic factors in the emergence of anxious-depressive phenotype in diabetic subjects, and whether the anxious-depressive phenotype in diabetic subjects is reversible by strategies targeting HPA axis dysfunctions.

More information about the unit can be found here : https://immuneendocrineandepigenetics.lih.lu

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.
 

Nature du financement

Financement public/privé

Précisions sur le financement

FNR - Project "Madam"

Présentation établissement et labo d'accueil

Luxembourg Institute of Health

The Allergology-Immunology-Inflammation research unit within the Department of Infection and Immunity focusses on different aspects of immune-related disorders, such as allergies, autoimmune diseases or cancers. It regroups specialists from different fields in order to address fundamental scientific questions and unmet medical needs.

Profil du candidat

Key Skills, Experience and Qualifications


• Master’s degree (or equivalent) in Molecular Biology or Genetics. Prior experience in epigenetics and DNA methylation would be an advantage, but is not mandatory.
• Good communication would be necessary to deal with the different partners involved in this project at the international level, as well as for restitution of the results to partners
• Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others.
• IT skills: Office, Outlook, Endnote if needed.
• Fluency in English is mandatory, French would be an asset.

Interested ? Please apply through the LIH website: www.lih.lu/jobs - Ref. VD/PHDS1017/JT/DII ALL6. Only applications sent via this link will be considered.

Date limite de candidature

30/11/2017
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