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Post doctoral position

ABG-80971 Emploi Confirmé
08/11/2018 CDD 24 Mois Salaire à négocier
IGBMC
Strasbourg - Grand Est - France
Biologie
Recherche et Développement

Employeur

IGBMC is one of the leading European centres in biomedical research. It is devoted to the study of higher eukaryotes genome and to the control of genetic expression as well as the functional analysis of genes and proteins. This knowledge is applied to studies of human pathologies.

Poste et missions

Title: New targets and pathways in neuroprotection – from bioactive metabolites to their traffic

PROJECT: The project aims at identifying mechanisms of neurodegeneration with the main focus on bioactive metabolites, which deficits were observed during aging and further exacerbated in several neurodegenerative diseases including Alzheimer or Parkinson disease. Such bioactive metabolites may act as ligands for transcription factors and are important for adaptive reprogramming of the organism, but their study is impeded due to lack of appropriate tools. We propose to use newly developed bioprobes to visualize such molecules and study their intracellular traffic between cellular organelles and its relevance for cell physiology and pathology. The same tools will be also employed to study inter-cellular traffic and blood-brain-barrier transfer of such molecules as mechanisms underlying adaptive processes and activity-dependent cellular communication. Studies will be carried out in mouse brain tissue preparations, organotypic and primary cell cultures using in vivo imaging and if necessary high-resolution imaging. Particular attention will go to neuron-neuron and neuron-astrocyte-microglia circuits.

Mobilité géographique :

Pas de déplacement

Profil

We are looking for highly motivated post-doctoral fellow, with good English level and background in cellular biology and cellular communication. Sound experience in confocal imaging is required, whereas knowledge of life imaging techniques will be useful. Similarly, good knowledge of primary cell culture or cell line techniques is necessary whereas experience with organotypic cultures will be useful.  Although any technical expertise in molecular biology can be acquired in the team, any previous experience in these techniques will be of benefit. The candidate should be willing to bring personal input to the challenging multidisciplinary project, write scientific papers, contribute to preparation of research grants and participate in animating team’s life.

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