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Post-doctoral position in Structural Biology, Marseille

ABG-82315 Emploi Junior
28/01/2019 CDD 24 Mois > 25 et < 35 K€ brut annuel
AFMB - CNRS & Aix-Marseille Université
Marseille - Provence-Alpes-Côte d'Azur - France
  • Biologie
Recherche et Développement


The Architecture et Fonction des Macromolécules Biologiques (AFMB) laboratory, overseen by the CNRS and AMU, is a center of structural biology localized on the Luminy campus in the South of Marseilles, France, and in partnership with INRA under contract. The aim of our researches, organized around six research teams, is to depict the architecture of proteins or macromolecular assemblies at the molecular level to understand the biological mechanisms which they govern. The description of interactions between macromolecules or a macromolecule and a ligand is also crucial to manipulate these complex molecules. Finally, to understand the molecular diversity of members of some protein families, we also analyze the big data issued from large-scale genome sequencing centers. State-of-the-art technological facilities accredited by the AMU/IBiSA/FRISBI label and a service for the production of single-domain antibodies support our activities. These infrastructures are used on a daily basis by the staff members and by external users. They are also an insightful support to teaching and training activities.

Poste et missions

A post-doctoral position funded by the ANR project GAGOsynthis available for a structural biologist in the team “Structural Glycobiology and Neurobiology” at the AFMB laboratory.

We are seeking for an enthusiastic, highly motivated and creative individual with solid knowledge and expertise in structural biology and biochemistry to investigate the structure-function relationships of enzyme complexes involved in heparan sulfate (HS) biosynthesis in collaboration with the groups of Hugues Lortat-Jacob and Guy Schoehn at IBS (Grenoble, France). In particular, we aim at deciphering how the concerted action of HS biosynthetic enzymes can encode defined oligosaccharide motifs along the polymer to modulate activity of various protein ligands.

Mobilité géographique :


Prise de fonction :



Candidates must have a recent Ph.D. (or being in the process of completing one) in a relevant field with a demonstrated record of productive research. Experience in protein expression, particularly in eukaryotic cells, in biochemistry, and in X-ray crystallography or single particle cryo-EM is highly desirable.


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