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Post-doc position in Strasbourg (FR)

ABG-82488 Emploi Confirmé
21/01/2019 CDD 24 Mois > 35 et < 45 K€ brut annuel
INSERM UMR_S 1113
Strasbourg - Grand Est - France
Biologie
  • Santé, médecine humaine, vétérinaire
Cadherin, cancer, IBD, digestive system, metabolism
Recherche et Développement

Employeur

INSERM is a public research organization dedicated to biomedicine and health that employs over 15 000 scientists, engineers and technicians in 365 labs spread across France.The INSERM unit UMR_S 1113 is based in Strasbourg, a dynamic and cosmopolitan city in the heart of Europe that harbors an outstanding scientific and academic community while remaining on human scale. The INSERM unit UMR_S 1113 brings together about fifty researchers and clinicians whose objective is to better understand the mechanisms of tumorigenesis (Team 1) and the response to treatments in order to develop innovative therapies (Team 2). This fundamental and translational research is carried on with a collegial spirit, using a wide range of techniques and models, and through access to quality equipment and state of the art technical platforms.

Site web :

Poste et missions

The candidate will apply to upcoming post-doctoral funding calls and boost the research of a team that focus on cadherin-related proteins, a heterogenous group of Ca2+-bindingmembranous glycoproteins that have been poorly studied compared with classical cadherins, in the context of the digestive system. If funded, the 2-3 years internship will start between September 2019 - January 2020 and may lead to permanent recruitment.

The scientific goal of the mission will be to better understand the role and the molecular mode of action of MUCDHL, which exhibits many atypical features, but emerges as playing a unique role in several organs of the digestive system (see references hereafter). Indeed, using patients’ samples and a mouse model knock-out model, the team has shown that the loss of MUCDHL leads to morphological and functional defects of the gut, as well as an increased sensitivity to intestinal diseases such as colon cancer and inflammatory bowel diseases (IBD).

The candidate will use various experimental models (inducible stable cell lines, organoïds, KO mice) and a large panel of reagents (plasmids, siRNA, antibodies) that have been developed and/or validated by the team to follow up unpublished data.The exact physio-pathological context of the project will be determined together with the candidate according to his background and interests, but will relate either to cancer, metabolism or IBD. The candidate is expected to fulfill all aspects of research (plan and carry on experimental work, analyze and present data…).

Hinkel IDuluc IMartin EGuenot DFreund JNGross I. Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.Gastroenterology. 2012 Apr;142(4):875-885.e3. doi: 10.1053/j.gastro.2011.12.037.

Crawley SW, Shifrin DA Jr, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, TyskaMJ. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.Cell. 2014 Apr 10;157(2):433-446. doi: 10.1016/j.cell.2014.01.067.

Mobilité géographique :

Pas de déplacement

Prise de fonction :

01/09/2019

Profil

We are urgently looking for a dynamic and highly motivated candidate having recently obtained a PhD degree, in molecular biology, cellular biology or related areas, or having completed a first post-doc abroad for at least 2 years. Technical skills should be in line with the goals of the project. Working with mice will be mandatory but prior experience is not exclusive.

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