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Ph.D. or M.Sc. position to study transcription factor function in stress response, inflammation and carcinogenesis

ABG-82895 Sujet de Thèse
08/02/2019 Salaire à négocier
Montreal - Canada
Ph.D. or M.Sc. position to study transcription factor function in stress response, inflammation and carcinogenesis
  • Biochimie
  • Biologie
  • Santé, médecine humaine, vétérinaire
cancer, stress response, inflammation, transcription factor, gene regulation, human and mouse models


A Ph.D. or M.Sc. position in Experimental Medicine (McGill) is available at the Lady Davis Institute for Medical Research/McGill University to study the role of bZIP transcription factors in the mammalian cell response to stress, inflammation and carcinogenesis. We use cell culture, in vivo mouse models and human specimens. We employ a variety of molecular, biochemical and cellular approaches, also including next generation sequencing (RNA-seq, ChIP-seq), bioinformatics and genome editing (CRISPR/Cas9).

- Saliba J, Coutaud B, Solovieva V, Lu F & Blank V. Regulation of CXCl1 chemokine and CSF cytokine levels in myometrial cells by the MAFF transcription factor. Journal of Cellular and Molecular Medicine. Jan 22, 2019 [epub ahead of print]

- Siegenthaler B, Defila C, Beer H-D, MeyerM, Tanner S, Bloch W, Blank V, Schäfer M & Werner S. Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion. Cell Death and Differentiation, 25:1749-1765, 2018                      

Kannan MB, Dodard-Friedman I & Blank V. Stringent control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) protein degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and glycogen synthase kinase 3 (GSK3). Journal of Biological Chemistry 2015, 290: 26292-302, 2015.

- Gasiorek JJ, Mikhael M, Garcia-Santos D, Hui ST, Ponka P & Blank V. Thioredoxin-interacting protein regulates the differentiation of erythroid precursors. Experimental Hematology 2015, 43: 393-403.

- Chevillard G, Paquet M & Blank V. Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood 2011, 117; 2005-2008.

Nature du financement

Contrat doctoral

Précisions sur le financement

Standard graduate student level

Présentation établissement et labo d'accueil


McGill University has been ranked consistently among the best universities in the world according to the Times Higher Education Supplement of 2006-2018. In 2019, McGill ranks 1st in Canada among medical-doctoral universities (Maclean’s) and 33rd in the world (QS World University Rankings). In 2019, the University was again one of Montreal’s Top Employers. The Lady Davis Institute for Medical Research and McGill University are located in Montreal, a very attractive bilingual, french-english speaking city.


Please note:

New Ph.D. (or M.Sc.) students can start the program in September 2019 (International applicant deadline April 2019, Canadians June 2019). 

More informaton on the graduate studies program (Ph.D. or M.Sc.) in Experimental Medicine can be found at the following website:


Intitulé du doctorat

Ph.D. in Experimental Medicine

Pays d'obtention du doctorat


Etablissement délivrant le doctorat

McGill University

Ecole doctorale

Profil du candidat

The candidate should have a recent Master II (Ph.D. student applicants) or B.Sc. equivalent (M.Sc. student applicants) and be competitive for obtaining a studentship (peer-reviewed publications, grades, ranking). Previous experience in molecular biology, tissue culture and/or human/mouse studies is required. Publications would be an asset.


Please provide your grade average as well as rank (License and/or Master I/II), 2-3 references (phone & e-mail) and a full CV (training/expertise/publications) and a short statement why you are interested in this position. The application can be either in English ou en français. Without this information your application cannot be considered.

Applicants will also need to pass a TOEFL (English as a foreign language) exam.


Date limite de candidature


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