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Post-Doc candidate to explore Ferritinophagy & Ferroptosis in cancer stem cells

ABG-83375 Emploi Niveau d'expérience indifférent
08/03/2019 CDD 24 Mois > 25 et < 35 K€ brut annuel
INSERM U1151
Paris - Ile-de-France - France
Biologie
  • Santé, médecine humaine, vétérinaire
Autophagy, cancer, stem cells, iron, metabolism,
Recherche et Développement

Employeur

This position will be based in Paris (France), at Institute Necker enfants Malades, a very attractive young institute. The successful applicant will join a dynamic environment of researchers and teachers in public health.

The project 
The aim of proposed research is to determine the role of iron homeostasis in the maintenance and emergence of cancer stem cells (CSCs). We believe that targeting iron metabolism in CSCs is a promising new approach to cancer therapy. The project is funded by INSERM and « la ligue contre le cancer » hold by Dr. Ahmed Hamaï. This project would answer the following purpose:

  1. Identify the molecular mechanism involved in the degradation of ferritin, iron storage protein, by lysosome to bring iron necessary to cell. 
  2. Identify the steps of initiation and executor of ferroptosis.

To answer this purpose, we have stem-like cellular models and transgenic mice developing spontaneously mammary tumors where CSCs have been identified.

For more detail do not hesitated to contact ahmed.hamai@inserm.fr.


Selected publication
 

  1. El Hout M, Dos Santos L, Hamaï A*, Mehrpour M. * A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells. Semin Cancer Biol. 2018 Dec;53:125-138. *Co-corresponding Authors
  2. Mai TT*, Hamaï A*, Hienzsch A*, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat Chem. 2017 Oct;9(10):1025-1033. *Co-first Authors
  3. Hamaï A, Mehrpour M. Autophagy and iron homeostasis Med Sci. 2017 Mars 33,  3, 260-267.
  4. Hamaï A, Cañeque T, Müller S, Mai TT, Hienzsch A, Ginestier C, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. An iron hand over cancer stem cells. Autophagy. 2017 Aug 3;13(8):1465-1466.
  5. Dupont N, Leroy C, Hamaï A, Codogno P. Long-Lived Protein Degradation During Autophagy. Methods Enzymol. 2017;588:31-40.
  6. Morel E, Mehrpour M, Botti J, Dupont N, Hamaï A, Nascimbeni AC, Codogno P. Autophagy: A Druggable Process. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:375-398.
  7. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.
  8. Yue W*, Hamaï A*, Tonelli G, Bauvy C, Nicolas V, Tharinger H, Codogno P, Mehrpour M.  Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy 2013 (5):714-29. *Co-first Authors
  9. Tuloup-Minguez V*, Hamaï A* , Greffard A, Nicolas V, Codogno P, Botti J. Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle. 2013 12 (20):3317-28. *Co-first Authors.
  10. Hamaï A, Pignon P, Raimbaud I, Duperrier-Amouriaux K, Senellart H, Hiret S, Douillard J-Y, Bennouna J, Ayyoub M, Valmori D. Human TH17 cells specific for the tumor antigen MAGE-A3 convert into IFN-γ secreting as they differentiate into effectors in vivo. Cancer Res. 2012;72 (5):1059-63.
  11. Hamaï A, Codogno P. New targets for acetylation in autophagy. Sci Signal. 2012; 5 (231):pe29.

Site web :

Poste et missions

The successful applicant will assist Dr. Hamaï in coordination, execution and valorisation of scientific activities related to the project, as follows:

  • Participate in the animation of the scientific life of the team
  • Plan, conduct and evaluate actions in adherence with project milestones and deliverables
  • Collaborate to data analysis and interpretation in compliance with standards of scientific integrity
  • Provide scientific/technical updating related to the area of expertise
  • Participate in the supervision of PhD students working on the project 

Benefits
Working as part of a young and motivated team in a scientifically stimulating surrounding.

 


 

Mobilité géographique :

Pas de déplacement

Profil

We are looking for a highly talented and motivated PhD graduate in molecular & cellular biology, genetics, immunology, public health, or similar scientific fields with a strong quantitative background. A solid experience in cancer biology, immunofluorescence microscopy and viral transduction are appreciated. Training in a variety of cell death analysis will be provided.

The post-holder must be creative, have a good track record and be at ease working both independently and as part of a team.

Objectifs

The successful applicant will assist Dr. Hamaï in coordination, execution and valorisation of scientific activities related to the project, as follows:

  • Participate in the animation of the scientific life of the team
  • Plan, conduct and evaluate actions in adherence with project milestones and deliverables
  • Collaborate to data analysis and interpretation in compliance with standards of scientific integrity
  • Provide scientific/technical updating related to the area of expertise
  • Participate in the supervision of PhD students working on the project 
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