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Post-doctoral position : development of 3D scaffolds for cancer therapy screening

ABG-83433 Emploi Junior
08/03/2019 CDD 12 Mois > 35 et < 45 K€ brut annuel
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CIRIMAT Institut Carnot Chimie Balard Cirimat
TOULOUSE CEDEX 09 - Occitanie - France
Matériaux
  • Santé, médecine humaine, vétérinaire
  • Sciences de l’ingénieur
biomaterial, biopolymers, physico-chemistry, 3D culture, cancer, chronic lymphocytic leukemia 
Recherche et Développement

Employeur

The « Phosphates, Pharmacotechnie, Biomatériaux" (i.e. Phosphates, Pharmaceutical technology, Biomaterials PPB) team of CIRIMAT gathers physico-chemists and pharmacist around multidisciplinary research themes. Our research is focused on synthesis, elaboration, characterization and reactivity study of inorganic, organic or composite materials for applications in various domains. The proposed post-doctoral position will be focused on organic biomaterials, made of biopolymers, and more precisely on their elaboration and characterization, including at the material/cell interface, for biomedical applications.

 

Our activities, from innovative materials and medical devices elaboration to technology transfer, are developed in interaction with socio-economic (SME, big groups, biomedical networks…) and/or academic partners at a regional, national and international level. The post-doctoral position described here is included in a pre-maturation project founded by the Occitanie (South-East) region of France, with regional academic partners.

Poste et missions

In the context of the pre-maturation project called MATRICELL, we propose a post-doctoral position of 1 year in the domain of biomaterials and translational research in oncology. This position will begin ideally in April but the dates can be adapted.

 

The goal of MATRICELL is to establish the proof of concept of innovative 3D scaffolds in the domain of cancerology. The steps of the project aim to explore the feasibility of use of scaffolds, initially developed to mimic soft tissues, for 3D cancer cell culture, taking chronic lymphocytic leukemia (CLL) as model.

 

With about 4500 new cases by year in France, chronic lymphocytic leukemia  is the most frequent leukemia of adult people; incurable, it results in 1000 deaths / year in Europe. In order to enhance the knowledge of oncogenesis and accelerate the development of targeted new therapies, tissue engineering concepts have emerged in oncology, with the goal to develop in vitro models mimicking the cellular microenvironment. If there is a consensus around the key role played by tumor microenvironment, its mechanism of action remains unclear. Its mechanical properties influence cell behavior, as well as its architecture and resulting cell confinement. In this context, developing a 3D model mimicking lymph node microenvironment, which could be used for treatment screening for patients in case of relapse with usual treatments, is the challenge of this project.

 

To answer this goal a pluridisciplinary consortium of academic partners have been constituted by MATRICELL’s project manager, Pr S. GIROD FULLANA, associating her research team CIRIMAT UMR CNRS 5085 (Team PPB) with I2MC (U1048 INSERM-UPS, Institut des Maladies Métaboliques et Cardiovasculaires, team 6), with the Service d’Hématologie de l'Institut Universitaire du Cancer de Toulouse Oncopole (IUCT-O), and team 9 of the Centre de Recherches en Cancérologie de Toulouse (CRCT).

 

Mobilité géographique :

Pas de déplacement

Prise de fonction :

15/04/2019

Profil

The candidate will have an expertise in biopolymers, processes of elaboration (including gelling and supercritical carbon dioxide drying methods) and/or characterization methods (determination of rheological and mechanical properties). Additional knowledge in fluorescence imaging (using confocal microscopy) and cell culture will be particularly appreciated. Teamworking and organizational skills are also needed.

 

Objectifs

The goal of MATRICELL is to establish the proof of concept of innovative 3D scaffolds in the domain of oncology. The steps of the project aim to explore the feasibility of use of scaffolds, initially developed to mimic soft tissues, for 3D cancer cell culture, taking chronic lymphocytic leukemia (CLL) as model. The project has begun in 2019/01/01 for 18 months. Developing a 3D model mimicking lymph node microenvironment, which could be used for treatment screening for patients in case of relapse with usual treatments, is the challenge of this project.

 

With the aim to move on from a TRL 2 to 4, the post-doctoral fellow will be in charge of MATRICELL’s Work-packages 1 and 2, i.e. of the elaboration and the characterization of the scaffolds. According to cell response, these WP will imply modification and/or optimization of the scaffolds ‘process of production (initially patented) and characterization of its consequences on scaffold’s behavior. Relationship between scaffold architecture and cell response will be particularly studied.

 

MATRICELL is a pre maturation project whose goal is providing a proof of concept before industrial transfer.

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