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4D analysis of microvessel for understanding Structuring the microvessel microenvironment with micr: JSPS Postdoctoral Fellowship on the project through the CNRS in Japan

ABG-91035 Emploi Junior
26/03/2020 Autre type de contrat > 35 et < 45 K€ brut annuel
LIMMS/CNRS-IIS (UMI 2820)
Tokyo - Japon
Biotechnologie
  • Physique
icrovessel on a chip, 3D cellular microenvironment, tissue engineering, microfluidics, image analysis, mathematical science, information technology
31/03/2020
Recherche et Développement

Employeur

LIMMS/CNRS-IIS UMI 2820 (Laboratory for Integrated Micro Mechatronic Systems) is an international laboratory between the French CNRS (Centre National de la Recherche Scientifique) and Institute of Industrial Science (IIS), The University of Tokyo, located in Komaba, Tokyo. LIMMS has more than 24 years of experience in international cooperative research and has welcomed more than 240 researchers from France and Europe.

 

LIMMS opens a new postdoctoral position in the laboratory of Professor Yukiko MATSUNAGA, Institute of Industrial Science, University of Tokyo, collaboration with Aurélien BANCAUD, LIMMS/CNRS-IIS (UMI 2820)

http://www.matlab.iis.u-tokyo.ac.jp/index.html

Poste et missions

Medical Biotechnology Lab at Institute of Industrial Science (IIS), The University of Tokyo, are working on microvessel models for the reconstruction of organ on a chip. In the modern bioengineering, complex microenvironment fabrication requires the assembly of multicellular components as well as a vascular network. We are interested in designing tissues mimicking physiological functions for understanding and visualizing disease mechanisms using microvessel model. The laboratory is well equipped with cell culture, microfluidics, and microscopy facilities and routinely cultures microvessels with increasing degree of complexity.

  The project consists of (i) designing sophisticated cellular microenvironments built on the microvessel model and (ii) perfusing the resulting microenvironment through the vascular network with microfluidic technologies. By doing so, we will engineer an organ on a chip and monitor its response to mechanical/biochemical cues in real time. Additionally, we will be able to perform target molecular analyses to characterize the physiology of this artificial tissue at the molecular level. By using the acquired 4D (3D + time course) information on the chip, we are interested in understanding physiological mechanism of blood vessels. The prospective postdoctoral researcher is expected to join and pursue this project. The position is open for the candidates from wide range of fields such as bioengineering, molecular biology, biomechanics, image analysis, mathematical science or information technology etc. are expected.

  • Fellowships are tenable for a period of between 12 and 24 months and must start in Japan during the period of 1 Septemer - 30 November 2020

Mobilité géographique :

Internationale

Profil

Candidates are expected to have a background of microfabrication technologies, microfluidics, and/or artificial tissue engineering, and have interests in bioengineering. A challenging spirit would help a lot for tackling this interdisciplinary and cutting-edge research area.

Objectifs

The prospective postdoctoral researcher should fabricate microvessels with microvessel-supporting stem cells and pilot the dynamic response of this microenvironment with a fluidic device. Furthermore, image analysis strategies as well as molecular analysis strategies will be implemented to characterize the physiology of the cellular system.

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