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Post doctoral fellow Immunometabolism UMR1011 Lille, France

ABG-93629 Emploi Niveau d'expérience indifférent
18/09/2020 CDD 12 Mois < 25 K€ brut annuel
INSERM UMR1011
Lille - Les Hauts de France - France
Santé, médecine humaine, vétérinaire
immunometabolism, liver, nonalcoholic fatty liver disease
Recherche et Développement

Employeur

INSERM UMR1011 is an internationally reknowned research group focused on the function of nuclear receptors in metabolic syndrome.

Poste et missions

Post-doctoral position in INSERM UMR1011 in Lille, France

Project: “Metabolic Activation of the Hepatic Immune System in Non-Alcoholic Steatohepatitis”

Project overview: This project is focused on understanding the molecular drivers of the pathogenesis of non-alcoholic steatohepatitis (NASH). The team has recently identified changes in various hepatic immune cell populations that associate with the development of NASH in an animal model and in humans. The fellow’s task is to determine how metabolic alterations associated with NASH (i.e. insulin resistance, hyperlipidemia) interact with the hepatic immune system and drive disease pathogenesis. The fellow will use state of the art tools (Seahorse/OroboROS, Metabolomics, 13C flux, Single Cell RNA-seq) to define the metabolic programs that support hepatic immune function in the context of NASH.

The project will be performed in INSERM UMR1011, a research unit affiliated to the European Genomic Institute of Diabetes (EGID) LabEx, INSERM, Institut Pasteur de Lille, CHU de Lille and Lille University. The unit develops interdisciplinary research at the interface of physiology, cell biology, biochemistry and medicine, hosts state-of-the art scientific services and technological platforms, and attracts students from around the world by offering high-level training in biomedical sciences.

We offer a 1-year contract (renewable for a second year) starting Nov 2020. This position was funded by the I-SITE foundation of Lille University. Remuneration and social benefits will be based on the INSERM agreement for public-sector employees. The applicant will be involved in a multidisciplinary group including basic scientists, clinicians and bioinformaticians, and integrated in international collaborations. They will have access to various technologies to perform this scientific project with high clinical relevance.

Your responsibilities will include:

- Molecular and biochemical analysis of cells and tissues of genetically modified mice

- Establishment of new techniques for metabolite analysis using in vivo models

- Bioinformatic/statistical analyses

 

Selected publications of the team:

Grzych G, Vonghia L, Bout MA, Weyler J, Verrijken A, Dirinck E, Joncquel M, Van Gaal L, Paumelle R, Francque S, Tailleux A, Haas JT, Staels B. Plasma BCAA changes in Patients with NAFLD are Sex Dependent. J. Clin Endo Metab 2020 Apr 9

Haas JT, Vonghia L, Mogilenko DM, Verrijken A, Molendi-Coste O, Fleury S, Deprince A, Nikitin A, Woitran E, Ducrocq-Geoffroy L, Pic S, Derudas B, Dehondt H, Gheeraert C, van Gaal L, Driessen A, Lefebvre P, Staels B#, Francque S#, Dombrowicz D# Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution. Nature Metabolism, June 2019

Mogilenko DA, Haas JT, Lhomme L, Levavasseur M, Becquart C, Wartelle J, Fleury S, Quemener S, Bogomolova A, Pineau L, Molendi-Coste L, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Marot G, Boulter A, Tavernier S, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D. Metabolic and Innate Immune Cues Merge Into a Specific Inflammatory Response via the UPR. Cell. 2019 May 16

Paumelle R, Haas JT, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi P, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B. Hepatic PPARalpha is critical in the metabolic adaptation to sepsis. Journal of Hepatology 2019 May

Mobilité géographique :

Européenne

Profil

Requirements. Applicants should have a PhD in any biological science with experience in animal experimentation. A background in immunology, bioinformatic analysis or lipid metabolism would be highly appreciated.

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