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In vitro evaluation of the pharmacological properties of neonicotinoids, sulfoximines and butenolides on insect and mammalian neuronal nicotinic acetylcholine receptors

ABG-97117 Sujet de Thèse
30/03/2021 Financement public/privé
Laboratoire de Biologie des Ligneux et des Grandes Cultures, Collegium Sciences et Techniques, Université d'Orléans, - BP 6759
orléans - Centre Val de Loire - France
In vitro evaluation of the pharmacological properties of neonicotinoids, sulfoximines and butenolides on insect and mammalian neuronal nicotinic acetylcholine receptors
  • Biologie

Description du sujet

Neuronal nicotinic acetylcholine receptors (nAChRs) are of particular interest because they
are the main target of neonicotinoid insecticides, which are important in agriculture and
veterinary medicine for controlling insect pests, and preventing transmission of insect borne
diseases.
In the present study, we aim to compare the mode of action of several insecticides on
neuronal nAChRs using two-electrode voltage clamp. The project will be conducted in
collaboration with chemists. Thus, the candidate should have good capacity for teamwork and
communication skills.

 

We are looking for an applicant with skills on electrophysiological studies (not necessary but
appreciated) and molecular biology. The hired Ph.D student will have to perform cRNA
preparation and oocyte injection

Nature du financement

Financement public/privé

Précisions sur le financement

Présentation établissement et labo d'accueil

Laboratoire de Biologie des Ligneux et des Grandes Cultures, Collegium Sciences et Techniques, Université d'Orléans, - BP 6759

The university of Orléans is located in the south of Paris (1h15 from Paris) and 20 min from
the downtown of Orléans. It comprises 26 research laboratories and around 20 000 students.
Life in Orléans is wonderful and not expensive. The Ph.D student could live in the downtown
of Orléans like many students. He/Her will have access to all laboratory’s equipment.

Profil du candidat

We are looking for an applicant with skills on electrophysiological studies (not necessary but
appreciated) and molecular biology. The hired Ph.D student will have to perform cRNA
preparation and oocyte injection.

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