Dynamique à long terme du microbiote respiratoire pendant la thérapie par modulateurs du canal CFTR // Long-term dynamics of the CF microbiota during CFTR modulator therapy

Despite significant advances in therapies targeting the underlying defect in cystic fibrosis (CF), airway infections remain a major driver of lung disease progression. Emerging CFTR modulators have the potential to reshape microbial community interactions, including the production of microbial effectors. This fellowship will investigate the long-term impact of the newest CFTR modulator therapy on the airway microbiome of CF patients. By integrating functional microbiome profiling with clinical data, the project aims to unravel microbiome dynamics and identify microbial effectors mediating pathogen–commensal interactions that could be leveraged to improve the management of airway infections.
This fellowship is part of the Marie Sklodowska-Curie Doctoral network METAMIC 3 - Metaproteome-based leveraged microbiome management in the context of One Health. METAMIC 3 is funded by the European Commission under the Horizon Europe framework programme (Grant Agreement number 101225682).
The METAMIC 3 project will embed Doctoral Candidates (DCs) in a unique training environment to advance microbiome science through metaproteomics. The program addresses One Health challenges by integrating research on microbial mechanisms, microbiome dynamics in various ecosystems, and translational applications in clinical and biotech fields. DCs will benefit from expertise across molecular biology, bioinformatics, clinical research, and environmental science, supported by collaborations among academia, industry, and public sector partners.

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Despite significant advances in therapies targeting the underlying defect in cystic fibrosis (CF), airway infections remain a major driver of lung disease progression. Emerging CFTR modulators have the potential to reshape microbial community interactions, including the production of microbial effectors. This fellowship will investigate the long-term impact of the newest CFTR modulator therapy on the airway microbiome of CF patients. By integrating functional microbiome profiling with clinical data, the project aims to unravel microbiome dynamics and identify microbial effectors mediating pathogen–commensal interactions that could be leveraged to improve the management of airway infections.
This fellowship is part of the Marie Sklodowska-Curie Doctoral network METAMIC 3 - Metaproteome-based leveraged microbiome management in the context of One Health. METAMIC 3 is funded by the European Commission under the Horizon Europe framework programme (Grant Agreement number 101225682).
The METAMIC 3 project will embed Doctoral Candidates (DCs) in a unique training environment to advance microbiome science through metaproteomics. The program addresses One Health challenges by integrating research on microbial mechanisms, microbiome dynamics in various ecosystems, and translational applications in clinical and biotech fields. DCs will benefit from expertise across molecular biology, bioinformatics, clinical research, and environmental science, supported by collaborations among academia, industry, and public sector partners.
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Pôle fr : Direction de la Recherche Fondamentale
Département : Institut des sciences du vivant Frédéric JOLIOT
Service : Service de Pharmacologie et Immunoanalyse
Date de début souhaitée : 01-04-2026
Ecole doctorale : Sciences Chimiques et Biologiques pour la Santé (CBS2)
Directeur de thèse : Grenga Lucia
Organisme : CEA
Laboratoire : DRF/JOLIOT/DMTS/SPI/LI2D
URL : https://www.linkedin.com/in/lucia-grenga-958703a5/
URL : www.progenomix.fr/en
URL : https://euraxess.ec.europa.eu/jobs/368508

Public/private mixed funding

Pôle fr : Direction de la Recherche Fondamentale
Département : Institut des sciences du vivant Frédéric JOLIOT
Service : Service de Pharmacologie et Immunoanalyse

Masters, Diploma or equivalent degree in biology, biochemistry, molecular medicine or similar