3D-printing of Shape-Morphing Biomaterials

The CERMAV is a leading research center in the field of natural polymer. More specifically, the candidate will work in the team “Structure and Modification of Polysaccharides” which employs modified polysaccharide molecules to design innovative materials for biomedical applications

Summary: This internship aims to develop innovative 3D-printable hydrogels capable of post-printing shape transformation, thereby mimicking the dynamic complexity of natural tissues. The primary objective is to synthesize a novel bio-ink—comprising a modified polysaccharide matrix and rigid microfibers—and to investigate both its 3D-printing properties and shape-morphing behavior.

The project will commence with the synthesis and characterization of the essential components: modified polysaccharides and rigid microfibers, which will be used to formulate the hydrogel bio-ink. Following ink preparation, the material will be 3D-printed using micro-extrusion. A key aspect of the work will involve optimizing printing parameters to ensure precise fiber alignment within the printed structures. Upon immersion in aqueous media, the anisotropic fiber orientation is expected to induce anisotropic swelling and, consequently, shape transformation. The resulting deformation will be systematically analyzed to elucidate its mechanisms and to guide the design of 3D constructs with complex, programmable shape-morphing behavior.

Skills that will be acquired during the internship: This project will give the student practical experience in the chemical modification of polymers, as well as the fabrication, processing, and characterization of soft materials—particularly hydrogels. The experimental work will cover the synthesis of components, the preparation and characterization of complex hydrogel systems, and the 3D printing and analysis of their shape-morphing behavior. A range of advanced techniques will be employed, including swelling studies, Ultrafiltration, NMR, rheology, 3D micro-extrusion printing, optical microscopy, and computer-assisted image analysis.

The candidate should have strong theoretical knowledge in polymer chemistry and physical chemistry. They should be curious, creative, proactive in facing technical challenges, and interested in “smart materials.” Good writing skills and work organization are also essential for the successful completion of this project.