Intracellular Persister Biology

CIRI is a leading research institute jointly affiliated to INSERM, CNRS, ENS Lyon and Lyon 1 University. CIRI gathers 400 scientists with a diverse panel of expertise ranging from molecular microbiology to human immunology. At the CIRI, we offer a dynamic and stimulating scientific environment at the heart of the Lyon Biodistrict, with strong links to clinical research and direct access to state-of-the-art technological platforms through the SFR Biosciences (UMS3444/US8). Located in a city renowned for its thriving biotech ecosystem and vibrant cultural life, Lyon also offers easy access to the French Alps, the Auvergne region, the Mediterranean Sea, and is just a two-hour train ride from Paris. It’s an ideal setting to pursue cutting-edge research while enjoying an exceptional quality of life.

Many pathogens are difficult to eradicate, even in the absence of genetically encoded antimicrobial resistance mechanisms and despite remaining susceptible to antibiotics in vitro. A subset of clonal bacteria can transiently withstand antibiotic treatment; these cells are known as antibiotic persisters. Increasing evidence highlights the pivotal role of the host cell environment in driving persister emergence. We are seeking a highly motivated postdoctoral scientist to investigate how bacterial persisters arise within macrophages. The successful candidate will develop innovative projects at the interface of cell biology, microbiology, and molecular biology, while leveraging cutting-edge single-cell technologies and multi-omics approaches. Candidates will also be encouraged to pursue independent ideas as they progress toward becoming an independent scientist.

At CIRI, the Persistence and single-cell dynamics of respiratory pathogens Lab led by Nicolas Personnic explores how heterogeneity, across scales, is generated and how it allows pathogens to evade antibiotic clearance. We welcome applications from individuals driven to decipher how heterogeneity impacts infection processes and persister biology, as well as those excited about pioneering new concepts and methods in quantitative single-cell biology. Candidates should hold a PhD degree in cell biology, with a strong publications record relative to their experience level. Experience in macrophage biology or other immune cell research is considered a plus. Team spirit is essential as well as an excellent oral and written communication skills in English.Scientists eligible for international postdoctoral mobility programs (eg. marie-sklodowska-curie-actions, …) supporting research in France are strongly encouraged to apply.