Pullulan modification via click chemistry, development of printable hydrogels, and advanced rheological characterization, targeting applications in controlled drug delive

Pullulan is a bio-based, biocompatible polysaccharide whose exceptional molecular regularity distinguishes it from other polysaccharides such as chitosan, dextran, or hyaluronan. This homogeneity enables precise chemical control, opening the way to well-controlled functional modifications and the design of smart materials. Although its biocompatible properties have been known for several decades, pullulan remains underexploited in the field of advanced materials, making it a promising platform for biomedical innovation.

This PhD project aims to transform pullulan into a polymer that is dually responsive to temperature and pH, capable of dynamically responding to its environment. In a first stage, chemical modification will be carried out using click chemistry, a modern approach combining speed, selectivity, and high yield, enabling the introduction of various functional groups onto the polymer’s hydroxyls. Other synthetic pathways will then be explored to fine-tune the material’s responsiveness and mechanical properties.

The second phase of the project will focus on processing and rheological characterization of the resulting polymers. Printable hydrogels will be developed and tested to optimize their viscoelastic properties and suitability for 3D printing. Their ability to encapsulate and release active agents in a controlled manner will then be evaluated, paving the way for applications such as targeted drug delivery or tissue regeneration.

This project will be conducted in collaboration with the University of São Paulo (Brazil) and the Cendre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), within Nicole Demarquette’s research chair on rheology for the development of new polymer systems at the École de technologie supérieure (ÉTS). This international synergy will provide a unique scientific environment at the intersection of polymer chemistry, advanced rheology, and bioengineering, giving rise to a new generation of smart materials.

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We are seeking a highly motivated candidate with a strong background in materials science, polymer science, chemical engineering, or a closely related field. The ideal candidate will have prior training in polymer chemistry and/or soft materials, with a solid understanding of structure–property relationships in macromolecular systems. Experience with hydrogel systems, polysaccharides, or bio-based polymers will be considered a strong asset.

The candidate should demonstrate interest and ideally experience in at least one of the following areas: chemical modification of polymers (e.g., click chemistry or functionalization of hydroxyl-containing polymers), rheological characterization of complex fluids and soft solids, formulation of hydrogels, or additive manufacturing/3D printing of soft materials. Familiarity with techniques such as FTIR, NMR, GPC/SEC, DSC, rheometry, or microscopy will be advantageous.

Given the interdisciplinary nature of the project, the candidate must be comfortable working at the interface of chemistry, materials science, and bioengineering. Strong analytical skills, scientific rigor, and the ability to design and interpret experiments are essential. Experience in data analysis (e.g., MATLAB, Python) and an interest in modeling structure–rheology–processing relationships will be considered an asset.

The candidate should be able to work both independently and as part of an international collaborative team, and demonstrate strong communication skills in English (knowledge of French is an asset). A strong interest in translational research and biomedical applications of polymeric materials is highly desirable.