Post-doctoral Fellow in Leukemia Research

The laboratory of Dr. Alexandre Puissant, a Team Leader and an Associate Professor in the Onco-Hematology department of the Saint Louis Research Institute & Hospital (https://gencelldis.fr/a-puissant-team/, Paris, France), is seeking a highly motivated post-doctoral fellow to identify and characterize metabolic and epigenetic determinants of Acute Myeloid Leukemia (AML) onset and progression.

Who Are We?

Our international lab employs large-scale screening, functional genomics, and proteomics in pre-clinical models to study altered cellular responses in leukemia. This work has uncovered leukemia-promoting targets, identified strategies to exploit leukemia dependencies, and provided new insights into cellular transformation and oncogenic mechanisms of leukemia onset and progression.

Combining state of the art functional genomics and proteomics in various AML models, our recent work has provided groundbreaking insights:

1- We identified critical targets for therapeutic intervention (Fenouille et al., Nature Medicine, 2017; Pardieu et al., Leukemia, 2022).

2- We showed that specific metabolic and epigenetic mechanisms can be manipulated to enhance cancer cell sensitivity to therapies (Su et al., Cancer Discovery, 2020; Lin et al., Nature Genetics, 2020; Nature Cancer, 2022).

3- We discovered specific targets to curb disease progression alongside standard treatments (Kelly et al., Nature Cancer, 2024).

Who Are We looking for?

We are looking for bright, ambitious, and collaborative scientists to join our dynamic and innovative team. The successful candidate will engage in exciting projects investigating how metabolic and epigenetic rewiring influence leukemia progression, utilizing diverse in vitro and in vivo systems.

Key responsibilities?

Design and perform in vitro and in vivo experiments to evaluate leukemia progression under genetic or pharmacological perturbations (cell line and primary cell infection and related cell culture assays, multiparametric flow cytometry-based techniques, disease monitoring in animals, organ collection).

Utilize advanced high-throughput functional CRISPR/shRNA-based techniques, transcriptomics, and epigenomics.

Stay current with technological and bibliographic developments.

Publish impactful research in leading journals.

Required Qualifications?

Ph.D. (or equivalent) in Biochemistry, Cell Biology, Molecular Biology, or a related field.

Strong research background with a solid publication record.

Expertise in biochemical and molecular biology techniques.

Experience with mouse models is highly valued.

Team player with a dynamic personality and a passion for innovation and problem-solving.

Independent, rigorous, and curious.

Why Joining Us?

World-Class Resources: Situated in the heart of downtown Paris, our research institute offers access to top-tier research facilities for exceptional fundamental and translational research. Surrounded by a dynamic scientific and clinical community, and vibrant city life, it provides a stimulating and collaborative environment.

Collaborative Opportunities: Our lab provides an interdisciplinary environment with opportunities for both international and local collaborations, working alongside leading research labs in Paris, Europe, and the US, at the forefront of various biological fields.

Mentorship and career development: Dr. Puissant is dedicated to guiding postdoctoral fellows towards success in academia, industry, or other professional endeavors.

Competitive benefits: Our research institution provides excellent compensation, including health insurance, with benefits that align with the cost of living and support personal development.

To Sum up:

Join us in advancing our understanding of the fundamental mechanisms of cancer development and exploring new therapeutic frontiers in a vibrant environment driven by dynamism, scientific curiosity, well-being, and the promotion of an inclusive and diverse research community.