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Structural Basis of Substrate Recognition by the Glycosaminoglycan Biosynthesis Machinery

ABG-140196 Thesis topic
2026-09-09 Public/private mixed funding
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Institut de Biologie Structurale - Equipe SAGAG
- Auvergne-Rhône-Alpes - France
Structural Basis of Substrate Recognition by the Glycosaminoglycan Biosynthesis Machinery
  • Biochemistry
Cryo-EM, NMR, protein-protein interaction, enzymatic assay, glycobiology

Topic description

A fully funded 3-year PhD position is available in the WILD team at the
Institut de Biologie Structurale (IBS) in Grenoble, France. The successful
candidate will contribute to a better understanding of the molecular
mechanisms underlying glycosaminoglycan biosynthesis. Our research
combines in vitro enzymatic assays with state-of-the-art biophysical
techniques, including nuclear magnetic resonance spectroscopy and
single-particle cryo-electron microscopy, to investigate substrate specificity and protein–protein interactions of key biosynthetic enzymes.

Funding category

Public/private mixed funding

Funding further details

ANR

Presentation of host institution and host laboratory

Institut de Biologie Structurale - Equipe SAGAG

You will join a young, dynamic, and international research team
working in an interdisciplinary environment. The Institut de Biologie
Structurale is located on the EPN campus in Grenoble and provides
excellent infrastructure for pursuing challenging structural biology
projects, as well as access to a vibrant scientific community.

PhD title

Doctorat de Biologie

Country where you obtained your PhD

France

Institution awarding doctoral degree

UNIVERSITE GRENOBLE ALPES

Graduate school

Chimie et sciences du vivant

Candidate's profile

We are looking for a highly motivated and team-oriented candidate with:

  • A Master’s degree in structural biology, protein biochemistry, or a related field.
  • Strong practical experience in protein purification and characterisation.
  • Previous experience in protein structure determination would be an advantage.
  • Excellent written and oral communication skills in English.
2026-10-31
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