Catalytic Asymmetric Cycloadditions towards Fluorinated Azacycles

This research proposal describes a three-year program in synthetic organic methodology aimed at developing broad access to stereodefined azacycles bearing fluorine atoms, which are highly valuable scaffolds in medicinal chemistry.
Based on our experience in palladium-catalyzed cycloadditions, the candidate will investigate the reactivity of new fluorinated precurors with the aim to perform diasetereo and enantioselective transformations using chiral metal ligands.

Do not hesitate to send an email if you want to discuss in more details about this project.

References

Scuiller, A.; Karnat. A.; Casaretto, N.; Archambeau, A. Org. Lett. 2021, 23, 2332-2336.
Scuiller, A.; Liu, X.; Cordier, M.; Garrec, J.; Archambeau, A. Synlett 2021, 32, 981-986.
Vitaku, E.; Smith, D. T.; Njardarson, J. T. J. Med. Chem. 2014, 57,10257-74.
Blakemore, D. C.; Castro, L.; Churcher, I.; Rees, D. C.; Thomas, A. W.; Wilson, D. M.; Wood, A. Nature Chem 2018, 10, 383.

The Laboratory of Organic Synthesis (LSO, UMR 7652) is a joint unit between CNRS, Ecole Polytechnique (Palaiseau, France) and ENSTA ParisTech (Palaiseau, France). Our research interests spans from the development of new methodologies, the total synthesis of natural products to the interfaces between organic chemistry and biology.

The applicant must have a strong background in the field of organic chemistry, organometallic catalysis and knowledge of good laboratory practice.