Implication des cellules immunitaires du SNC et périphériques à la neurodégénérescence dans des modèles de SLA

POSITION

You are passionate about neurodegeneration and neuroinflammation? You are interested in preclinical approaches? Join the Team of Severine Boillee at the ICM/PBI and participate in medical research in the field of neuroscience. We work on mechanisms that influence motor neuron degeneration and disease progression in amyotrophic lateral sclerosis (ALS). We showed, in ALS mouse models, that immune cells participate to disease progression. The mechanisms related to the interactions between immune cells and motor neurons leading to neurodegeneration are still poorly understood. The goal of this thesis project is to modulate the immune system together with its infiltration in the central nervous system (CNS) in ALS mouse models and to analyze the interactions between immune and neuronal cells and the impact on ALS disease progression.

MAIN MISSIONS

- Optimize the treatment protocol,

- Analyze disease progression in mouse models of ALS undergoing immunomodulatory treatments,

- Study the contribution of immune cells in the CNS and at the periphery,

- Study the interactions between immune cells and motor neurons.

The Paris Brain Institute (PBI) is a private foundation recognized as being of public utility, whose purpose is fundamental and clinical research on the nervous system. On the same site, 800 researchers, engineers and physicians (from Inserm, CNRS, APHP, Sorbonne University, ICM/PBI) cover all the disciplines of neurology, with the aim of accelerating discoveries on brain function, and the development of treatments for neurological and neurodegenerative diseases.

Knowledge

- You have a master’s degree (M2 or equivalent) in neuroscience, immunology or physiology,

- You have already completed at least two internships in two different laboratories or have a professional experience in a research laboratory,

- You have already worked in the field of neurodegeneration/ neuroinflammation/ neuroscience/ immunology, particularly using mouse models.

Hard skills

- You have experience working with mouse models,

- You have knowledge in immunohistochemistry and image analysis,

- You have experience in cytometry and transcriptomics,

- You can use bioinformatics tools, 

- Fluency in technical English required.

Soft skills

- Rigorous and committed,

- highly motivated by research,

- You enjoy implementing new techniques and using new technologies,

- You like teamwork, to train others and to transmit your knowledge,

- You are autonomous but like to interact with your supervisor.