Engineer/post-doctoral position in genomics

The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation

A 2-year engineer or post-doctoral position funded by an ANR/DFG grant is open from the beginning of 2026 to work on the international France-Germany project in the group headed by Dr. Julie Soutourina at the Institute for Integrative Biology of the Cell (I2BC), Genome Biology department on the Gif-sur-Yvette campus of the CNRS (Paris region, France).

The engineer/post-doctoral fellow will participate in the interdisciplinary collaborative project to improve our understanding of the molecular mechanisms involved in Mediatorpathies. These rare neurodevelopmental diseases are associated with mutations in subunits of Mediator, an essential coregulator complex highly conserved from yeast to human cells. We aim in understanding the molecular consequences of the identified pathological variants in Mediator subunits on transcription and transcription-coupled DNA repair (TCR) and their impact on neurodevelopment. We propose to take advantage of the yeast Saccharomyces cerevisiae model and human cells to study transcriptional and TCR activities of transposed Mediator variants using genomic approaches. A bioinformatic analysis of NGS data will help to understand underlying mechanisms and their conservation from yeast to human cells.

The successful candidate will have a PhD or Master degree in molecular biology with solid knowledge in genetics and functional genomics. We are seeking for highly motivated candidates with a strong interest in the field of transcription and DNA repair in eukaryotes. A previous experience on yeast model and/or human cells, and genome-wide approaches, in particular ChIP-seq, is strongly required. An interest or previous experience in bioinformatic analyses of NGS data will be a plus.