Synthesis and studies of organic dyes and dyes aggregates for biological applications

Host laboratory: The Laboratoire Lorrain de Chimie Moléculaire, located in Vandoeuvre-les-Nancy, France, is a young laboratory dedicated to molecular chemistry and its applications. It brings together »70 members including synthetic chemists, physical chemists, nanomaterials specialists and biologists.

Project: Dyes aggregates (H/J-aggregates) are fascinating supramolecular structures formed through the self-assembly of organic dye molecules. Thanks to their remarkable optical properties, these dye aggregates hold great promise for applications in photodiagnosis and phototherapy. However, achieving precise control over their formation remains a major challenge in supramolecular chemistry. This project focuses on the synthesis of cyanine 5/7 dyes using targeted molecular design strategies to direct their aggregation behaviour.

Reference : Ma, X. et al. ChemMedChem 2023, 18 (15), e202300204.

Position: The work will mostly consist in organic synthesis and characterization (NMR, Mass spectrometry) of various cyanines dyes. In a second time, aggregation studies and specific properties relevant to the applications will be explored.

Profile: You should hold a Master 1 degree in organic chemistry or related field, with at least one practical experience in the lab. Interest/experience in dyes chemistry or spectroscopy studies would be appreciated. Autonomy, reliability, and organization skills are highly required, together with interest in a multidisciplinary approach. The project offers an exceptional opportunity for a highly motivated student to develop a broad range of competencies within research areas that hold significant academic and industrial relevance.