PhD Student in Cancer Epitranscriptomics

Background and Research Environment

Recently established, the Cancer RNAs & Epigenetic Group (CREG) focuses on understanding the role of epigenetic and epitranscriptomic regulation in tumor progression, with the ultimate aim to develop innovative nucleic acid therapeutics against cancer. We make use of advanced molecular and cellular technologies to identify novel targets and get insight into mechanisms deregulated in cancer. We are looking for a highly motivated Ph.D. student to join our young and dynamic research group. The successful candidate will get access to several core facilities and relevant state-of-the-art technologies. S/He will benefit from an active seminar program, international conference attendances, opportunities  for professional growth. The project will be carried out in collaboration with national and international partners.

The PhD candidate will be supported through a FNRS-Televie funded project focusing on the crosstalk between m6A RNA methylation pathway and metabolic/lipid rewiring in glioma. We will leverage our expertise in genetic engineering and m6A profiling, and characterize the specific metabolome and lipidome composition of glioma.  We will assess the impact of m6A deregulation on glioma oncogenic features.
 

The Luxembourg Institute of Health (LIH) is a public biomedical research organisation focused on precision health and invested in becoming a leading reference in Europe for the translation of scientific excellence into meaningful benefits for patients. LIH places the patient at the heart of all its activities, driven by a collective obligation towards society to use knowledge and technology arising from research on patient-derived data to have a direct impact on people’s health. Its dedicated teams of multidisciplinary researchers strive for excellence, generating relevant knowledge linked to immune related diseases and cancer. The institute embraces collaborations, disruptive technology and process innovation as unique opportunities to improve the application of diagnostics and therapeutics with the long-term goal of preventing disease.

Key Skills, Experience and Qualifications

• Master’s degree in Biomedical Sciences, Biology, or Oncology
• Hands-on experience in molecular biology, cell culture (2D and 3D), immunofluorescence and microscopy
• Prior experience in RNA biology, NGS and/or Metabolism is an asset
• Understanding of common bioinformatics approaches and experience with one of the main programming languages for data analysis (R, Python) is an asset.
• Curiosity, creativity, rigor, willingness to learn, team spirit and collaborative capacity, excellent time and priority management.
• Fluency in English  (written and spoken) is mandatory